{"id":"W1995498713","doi":"10.1097/01.hjh.0000166845.49850.39","title":"Negative regulation of RhoA/Rho kinase by angiotensin II type 2 receptor in vascular smooth muscle cells: role in angiotensin II-induced vasodilation in stroke-prone spontaneously hypertensive rats","year":2005,"lang":"en","type":"article","venue":"Journal of Hypertension","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal","funders":"","keywords":"RHOA; Fasudil; Angiotensin II; Endocrinology; Valsartan; Internal medicine; Rho-associated protein kinase; Vasodilation; Vascular smooth muscle; Medicine; Angiotensin II receptor type 1; Spontaneously hypertensive rat; Mesenteric arteries; Vasoconstriction; Renin–angiotensin system; Agonist; Receptor; Biology; Signal transduction; Artery; Cell biology; Blood pressure; Smooth muscle","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001864066,0.000566198,0.0006935605,0.0003879512,0.0002123734,0.0002894792,0.0001976656,0.0003294758,0.001696118],"category_scores_gemma":[0.00009848284,0.00027621,0.0004896519,0.0001885206,0.000320189,0.0002687615,0.0001708207,0.0008615736,0.0004235017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001959949,"about_ca_system_score_gemma":0.0002084281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000510344,"about_ca_topic_score_gemma":0.0007895864,"domain_scores_codex":[0.9998123,0.00003189277,0.00001977187,0.00003392204,0.00004317504,0.00005896293],"domain_scores_gemma":[0.9998022,0.000009737274,0.00006185048,0.00002476705,0.00001839218,0.00008316941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003765356,0.00008073339,0.0002906107,0.00004013877,0.00000841319,0.0001033981,0.00001550468,0.00001492543,0.9983678,0.0000377824,0.00003059549,0.0006334836],"study_design_scores_gemma":[0.0001393044,0.001861151,0.04295665,0.00001631137,0.00009643832,0.0006931716,0.000114621,0.0009202424,0.9517719,0.00008573108,0.001329482,0.00001500365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970502,0.001073327,0.0009404413,0.0001192975,0.00003137827,0.00002030014,0.0001945568,0.00005549117,0.0005150552],"genre_scores_gemma":[0.992971,0.001817665,0.001513248,0.00007336651,0.00004405836,0.0001305141,0.0004685158,0.00002719018,0.002954389],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001696118,"threshold_uncertainty_score":0.005674064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01151944962789493,"score_gpt":0.2154951401480884,"score_spread":0.2039756905201935,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}