{"id":"W1995500998","doi":"10.1111/tpj.12228","title":"Downregulation of multiple <scp>CDK</scp> inhibitor <i><scp>ICK</scp>/<scp>KRP</scp></i> genes upregulates the E2F pathway and increases cell proliferation, and organ and seed sizes in Arabidopsis","year":2013,"lang":"en","type":"article","venue":"The Plant Journal","topic":"Plant Molecular Biology Research","field":"Agricultural and Biological Sciences","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"","keywords":"Downregulation and upregulation; Cyclin-dependent kinase; Arabidopsis; E2F; CDK inhibitor; Cell growth; Cell biology; Gene; Cell cycle; Chemistry; Cancer research; Biology; Biochemistry; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006260683,0.0005136678,0.000268338,0.0003340183,0.0001508259,0.0002826634,0.0002326886,0.0001458286,0.0008389573],"category_scores_gemma":[0.00008644514,0.000217681,0.0002705016,0.0001743702,0.0002411199,0.0002059135,0.0002287039,0.0004962133,0.000287991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005436269,"about_ca_system_score_gemma":0.0002752568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001548192,"about_ca_topic_score_gemma":0.002403588,"domain_scores_codex":[0.9998897,0.000007231125,0.00001386942,0.00003455928,0.00002898113,0.00002563815],"domain_scores_gemma":[0.9998316,0.00002083457,0.0000527575,0.00002296265,0.00001397345,0.00005784665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003430213,0.00000697013,0.0001336275,0.0000149503,0.000002461751,0.00002576037,0.000004976456,0.0000482668,0.9992545,0.00003290845,0.00001265775,0.0004285032],"study_design_scores_gemma":[0.000008761956,0.00005729654,0.006904286,0.000003529498,0.00001959106,0.0001833161,0.00001852811,0.0008081988,0.990808,0.00002173782,0.001161758,0.000005171227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962686,0.0007007502,0.001548891,0.00003489229,0.00001101381,0.00001305255,0.0004037416,0.0001209896,0.0008979577],"genre_scores_gemma":[0.9954022,0.0004738573,0.001579946,0.00003346932,0.000005824927,0.00002396682,0.0005471322,0.00006897921,0.001864478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001548192,"threshold_uncertainty_score":0.003944278,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01128354081601398,"score_gpt":0.185284329617733,"score_spread":0.174000788801719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}