{"id":"W1995535465","doi":"10.1016/j.chembiol.2013.03.014","title":"Modulation of Fatty Acid Synthase Enzyme Activity and Expression during Hepatitis C Virus Replication","year":2013,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; National Research Council Canada; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Fatty acid synthase; Biology; Hepatitis C virus; Viral replication; Enzyme; Enzyme assay; Fatty acid; Fatty acid synthesis; Molecular biology; Virology; Biochemistry; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001029224,0.000100998,0.0002171897,0.0000319436,0.00005094443,0.000006507573,0.00006256213,0.0001981154,0.0005581744],"category_scores_gemma":[0.0004592058,0.00009139203,0.00003344603,0.00007608498,0.000147284,0.00008536919,0.00008636943,0.0001580239,0.00001752444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006378478,"about_ca_system_score_gemma":0.00003555764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008609671,"about_ca_topic_score_gemma":0.00000925313,"domain_scores_codex":[0.9991421,0.00004105983,0.0001899153,0.0003461961,0.00009868712,0.0001820395],"domain_scores_gemma":[0.9991242,0.00004675172,0.0001036838,0.0004847274,0.0001241031,0.0001164849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004947017,0.00005167239,0.09904113,0.0001937606,0.00001080458,0.000001997083,0.00002740432,3.979609e-7,0.8811197,0.000001316532,0.00004021322,0.01946215],"study_design_scores_gemma":[0.0003257412,0.00003404534,0.2171223,0.00004216247,0.000005093091,0.000009149952,0.000003827022,0.0007015335,0.7815481,0.00003415336,0.0001161788,0.00005772638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980844,0.0001242097,0.000384247,0.0002008037,0.00001558189,0.0002597236,0.0000292841,0.00003593079,0.0008658217],"genre_scores_gemma":[0.9987912,0.0003490878,0.0004171557,0.000014604,0.00007129597,0.00008472642,0.00007254974,0.00001154417,0.0001878663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1180812,"threshold_uncertainty_score":0.6111618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02263001353575108,"score_gpt":0.3094938177667818,"score_spread":0.2868638042310308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}