{"id":"W1995556150","doi":"10.1081/ncn-100105246","title":"SYNTHESIS OF UNNATURAL 7-SUBSTITUTED-1-(2-DEOXY-β-D-RIBOFURANOSYL)ISOCARBOSTYRILS<sup>†</sup>: “THYMINE REPLACEMENT” ANALOGS OF DEOXYTHYMIDINE FOR EVALUATION AS ANTIVIRAL AND ANTICANCER AGENTS","year":2001,"lang":"en","type":"article","venue":"Nucleosides Nucleotides & Nucleic Acids","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Cytotoxicity; Thymidine kinase; Herpes simplex virus; Cytotoxic T cell; Transfection; Chemistry; Thymine; Stereochemistry; Nucleoside; Nucleoside analogue; Cell culture; Thymidine; In vitro; Gene; Biology; Virus; Virology; Biochemistry; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001072324,0.0006956417,0.001430453,0.0005841373,0.0002521765,0.00005256178,0.0002982376,0.0003116039,0.0006740828],"category_scores_gemma":[0.00102959,0.0006186472,0.0004269119,0.000805784,0.0006093873,0.0004980367,0.0001585996,0.0002547191,0.00004204023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002885631,"about_ca_system_score_gemma":0.0003041191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001326186,"about_ca_topic_score_gemma":0.00002712889,"domain_scores_codex":[0.9955424,0.0001644843,0.001371401,0.0009630167,0.00116358,0.0007950818],"domain_scores_gemma":[0.9970688,0.0004602586,0.0006149388,0.0008013794,0.0007423812,0.0003122256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01242462,0.003420211,0.7486988,0.002115208,0.005494007,0.0002115341,0.005496613,0.000244882,0.08690149,0.004810287,0.00965921,0.1205231],"study_design_scores_gemma":[0.04200734,0.004383368,0.553968,0.005245737,0.01166639,0.0006487602,0.005688029,0.06988225,0.2711449,0.002770978,0.02942463,0.003169706],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902877,0.001001047,0.00006860471,0.002091013,0.0001863097,0.002250221,0.000105052,0.0001408916,0.003869212],"genre_scores_gemma":[0.9911661,0.001309403,0.005877455,0.0002797191,0.0001616754,0.0001479424,0.0001750386,0.0001359443,0.0007467753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1947309,"threshold_uncertainty_score":0.9996265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0188142465237849,"score_gpt":0.2934158386926181,"score_spread":0.2746015921688332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}