{"id":"W1995556150","doi":"10.1081/ncn-100105246","title":"SYNTHESIS OF UNNATURAL 7-SUBSTITUTED-1-(2-DEOXY-β-D-RIBOFURANOSYL)ISOCARBOSTYRILS<sup>†</sup>: “THYMINE REPLACEMENT” ANALOGS OF DEOXYTHYMIDINE FOR EVALUATION AS ANTIVIRAL AND ANTICANCER AGENTS","year":2001,"lang":"en","type":"article","venue":"Nucleosides Nucleotides & Nucleic Acids","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Cytotoxicity; Thymidine kinase; Herpes simplex virus; Cytotoxic T cell; Transfection; Chemistry; Thymine; Stereochemistry; Nucleoside; Nucleoside analogue; Cell culture; Thymidine; In vitro; Gene; Biology; Virus; Virology; Biochemistry; DNA; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009900599,0.0003599318,0.0002723075,0.00008486718,0.00007815931,0.0002087111,0.0004141363,0.0002506117,0.001241908],"category_scores_gemma":[0.0001322718,0.0001301526,0.0001881188,0.0001120599,0.0001151729,0.0001804909,0.0001213925,0.0003836468,0.000493493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001776257,"about_ca_system_score_gemma":0.0001370399,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000198259,"about_ca_topic_score_gemma":0.0002574562,"domain_scores_codex":[0.9999233,0.00001265487,0.000008406231,0.00001964546,0.00001994825,0.00001596003],"domain_scores_gemma":[0.9999014,0.00001019311,0.0000328749,0.00001093903,0.00001871461,0.00002581705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001771547,0.0000298919,0.0001137462,0.00007223531,0.000007168208,0.00008781889,0.00001850004,0.000411517,0.9936942,0.0002520137,0.000111193,0.005024365],"study_design_scores_gemma":[0.00003810122,0.0006217683,0.0005655556,0.000005204158,0.00002184414,0.0003420243,0.00001071779,0.0009047003,0.9924803,0.00003268186,0.004966797,0.00001026247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810631,0.00206912,0.01019494,0.00006635905,0.00008070034,0.0001099893,0.0005931263,0.0001873287,0.00563538],"genre_scores_gemma":[0.982012,0.001097679,0.0132016,0.00008274472,0.00001898975,0.0001116532,0.001138458,0.00005832166,0.002278569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001241908,"threshold_uncertainty_score":0.004154623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0188142465237849,"score_gpt":0.2934158386926181,"score_spread":0.2746015921688332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}