{"id":"W1995560549","doi":"10.1182/blood-2006-10-047951","title":"Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":217,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Care Ontario; Eli Lilly and Company","keywords":"Bortezomib; Melphalan; Bone marrow; Multiple myeloma; Cytotoxicity; Cancer research; Dexamethasone; Pharmacology; Medicine; Biology; Immunology; Internal medicine; In vitro; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003870905,0.0008049748,0.0005891956,0.0003835877,0.0002169117,0.000406281,0.0006742126,0.0004860286,0.00189489],"category_scores_gemma":[0.0001519646,0.0002167258,0.0004359388,0.0003472809,0.000294585,0.0003912059,0.0003296712,0.001139384,0.0004022472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005386177,"about_ca_system_score_gemma":0.0006306148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009204088,"about_ca_topic_score_gemma":0.002437938,"domain_scores_codex":[0.9999005,0.00002268094,0.000007043431,0.00001389052,0.00002054692,0.00003543036],"domain_scores_gemma":[0.999898,0.00001106159,0.00002191813,0.000008622178,0.00001001017,0.00005045016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01003172,0.009520765,0.00166998,0.0008465881,0.0002828994,0.0003377495,0.0001795228,0.003946897,0.8753309,0.0009527335,0.001616706,0.09528352],"study_design_scores_gemma":[0.009839744,0.2846489,0.01636839,0.0001531096,0.0006101234,0.001467497,0.0001531296,0.003698869,0.65009,0.0005486821,0.03237464,0.00004691737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824843,0.008664325,0.002213674,0.0003145566,0.00009181912,0.001027153,0.0006302021,0.0002509866,0.004323015],"genre_scores_gemma":[0.9859475,0.00702102,0.002076411,0.0002388471,0.00003488465,0.0004120768,0.001424843,0.00002361843,0.002820821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00189489,"threshold_uncertainty_score":0.006339014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0854462178360637,"score_gpt":0.3807883635765643,"score_spread":0.2953421457405006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}