{"id":"W1995569350","doi":"10.1177/1074248408331018","title":"Gender-related Differences in Drug-induced Prolongation of Cardiac Repolarization in Prepubertal Guinea Pigs","year":2009,"lang":"en","type":"article","venue":"Journal of Cardiovascular Pharmacology and Therapeutics","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Medicine; Dofetilide; Verapamil; hERG; Internal medicine; Prolongation; Cardiology; Domperidone; QT interval; Torsades de pointes; Long QT syndrome; Repolarization; Afterdepolarization; Amiodarone; Endocrinology; Electrophysiology; Potassium channel; Atrial fibrillation; Dopamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002226417,0.0002040007,0.0003156297,0.0002879413,0.0001538585,0.0002336804,0.0001356455,0.0002816415,0.002327357],"category_scores_gemma":[0.0002522425,0.0001770827,0.0002579607,0.00007757013,0.0002878991,0.0002705496,0.0002054809,0.0005260555,0.0003819459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001673726,"about_ca_system_score_gemma":0.0001202667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003098111,"about_ca_topic_score_gemma":0.0006052203,"domain_scores_codex":[0.9998329,0.00003201032,0.00001494818,0.00005266949,0.00002586812,0.00004166869],"domain_scores_gemma":[0.9997557,0.00003823297,0.00009778552,0.00002092733,0.00002429204,0.00006317574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002104469,0.0001778141,0.005040531,0.00008905839,0.00001371167,0.0006728988,0.0001399814,0.00001757528,0.9875162,0.00009106772,0.00009020129,0.004046594],"study_design_scores_gemma":[0.0002167444,0.01690201,0.5990978,0.00006807694,0.0001712493,0.00557101,0.001024447,0.0003874414,0.3689516,0.0002603106,0.007286149,0.00006320501],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969408,0.001397995,0.0005399977,0.00007258127,0.00003763015,0.00003134094,0.0002736936,0.00001084398,0.0006950166],"genre_scores_gemma":[0.9951673,0.00151216,0.0006357039,0.0001758689,0.00002379965,0.0001260404,0.0003485054,0.00001443054,0.001996247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002327357,"threshold_uncertainty_score":0.007785797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01802172966894032,"score_gpt":0.2797999990276919,"score_spread":0.2617782693587516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}