{"id":"W1995576776","doi":"10.1021/jm034103e","title":"Selective Formation of Homo- and Heterobivalent Peptidomimetics","year":2003,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute","keywords":"Peptidomimetic; Chemistry; Bivalent (engine); Combinatorial chemistry; Stereochemistry; Fluorescence; Cell sorting; Receptor; Molecule; Computational biology; Biophysics; Biochemistry; Cell; Peptide; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003903064,0.0004255338,0.000442594,0.0003007121,0.0002176587,0.0004167189,0.0004805424,0.0003488202,0.001566477],"category_scores_gemma":[0.0003278427,0.000301195,0.0001454825,0.0002154082,0.0002086186,0.0002882435,0.0004885943,0.0008090478,0.0008250406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003492819,"about_ca_system_score_gemma":0.0002231328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001995806,"about_ca_topic_score_gemma":0.0006568563,"domain_scores_codex":[0.9996201,0.00005178023,0.00003486593,0.00009048874,0.000144905,0.00005778491],"domain_scores_gemma":[0.9998391,0.00002384925,0.00004632593,0.00002074445,0.00002529865,0.00004473774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000590944,0.0000170003,0.00003518265,0.00004329814,0.000005432474,0.00002193634,0.00001350374,0.0001038608,0.9960098,0.0002542507,0.00007115024,0.003365374],"study_design_scores_gemma":[0.00002814038,0.0002564219,0.000242862,0.000004621898,0.00001231723,0.0001689124,0.000008895307,0.0007027389,0.9941891,0.00004736028,0.004331894,0.000006712756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8744758,0.003824782,0.1069557,0.0003516278,0.0002555221,0.001007047,0.0009953541,0.0008837637,0.01125038],"genre_scores_gemma":[0.9049582,0.002480515,0.08104353,0.0003309555,0.00004826314,0.0005446058,0.001143782,0.0001497939,0.009300347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001566477,"threshold_uncertainty_score":0.005240381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005518668204814814,"score_gpt":0.223686325595809,"score_spread":0.2181676573909942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}