{"id":"W1995576776","doi":"10.1021/jm034103e","title":"Selective Formation of Homo- and Heterobivalent Peptidomimetics","year":2003,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute","keywords":"Peptidomimetic; Chemistry; Bivalent (engine); Combinatorial chemistry; Stereochemistry; Fluorescence; Cell sorting; Receptor; Molecule; Computational biology; Biophysics; Biochemistry; Cell; Peptide; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002677819,0.00007848769,0.0001946772,0.00001796385,0.00001874934,0.000004431447,0.00006971681,0.0000798243,0.00002736633],"category_scores_gemma":[0.000312035,0.00006130147,0.0001087687,0.00005306089,0.00006798243,0.000003939867,0.00001486038,0.0001009444,1.762752e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001467972,"about_ca_system_score_gemma":0.00003792864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.756188e-7,"about_ca_topic_score_gemma":2.33005e-7,"domain_scores_codex":[0.9993199,0.00002263854,0.0003215184,0.00007682366,0.0001715332,0.0000876479],"domain_scores_gemma":[0.9993476,0.000020691,0.0003037461,0.00008226185,0.0001611493,0.0000845016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004898532,0.00004463589,0.0006601566,0.0000773077,0.00005857519,0.00000195579,0.00003120349,0.000006268944,0.9978878,0.000002687631,0.0005179741,0.0006624001],"study_design_scores_gemma":[0.0004845165,0.0001212642,0.000150877,0.00006265993,0.00008536124,0.0002181705,0.0001963245,0.0000136597,0.9960323,0.0000622381,0.002512727,0.00005989315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958708,0.001652641,0.001119795,0.00007176065,0.00002004501,0.0000176859,0.000001945549,7.078004e-7,0.001244663],"genre_scores_gemma":[0.9986286,0.0005412083,0.0005642228,0.00002992262,0.0001281921,4.973187e-7,0.000002874473,0.000005216843,0.00009930988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002757799,"threshold_uncertainty_score":0.2499801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005518668204814814,"score_gpt":0.223686325595809,"score_spread":0.2181676573909942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}