{"id":"W1995584427","doi":"10.1021/bi0495230","title":"Transmembrane Helix 11 of Multidrug Resistance Protein 1 (MRP1/ABCC1):  Identification of Polar Amino Acids Important for Substrate Specificity and Binding of ATP at Nucleotide Binding Domain 1","year":2004,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Transmembrane domain; ATP-binding cassette transporter; ABCC1; Cyclic nucleotide-binding domain; Biochemistry; Transmembrane protein; Mutagenesis; Transport protein; Amino acid; Protein structure; Chemistry; Biology; Biophysics; Mutation; Transporter; Nucleotide; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001210235,0.0002816828,0.0001806179,0.0001332809,0.0001667958,0.0002026085,0.0001518062,0.0004151915,0.001160099],"category_scores_gemma":[0.0001559079,0.00009649646,0.0002205426,0.000169899,0.0001933186,0.0001464157,0.0001976503,0.0002995938,0.0006376721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002929181,"about_ca_system_score_gemma":0.0001914413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006193939,"about_ca_topic_score_gemma":0.0006632443,"domain_scores_codex":[0.9999244,0.0000139788,0.000006309544,0.00002054283,0.00001924481,0.00001559161],"domain_scores_gemma":[0.9999056,0.00001306492,0.00003411305,0.000005418749,0.00001257474,0.00002928454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002785631,0.00001574804,0.002019219,0.00005232478,0.00000616925,0.0002546297,0.00003044229,0.0001252478,0.9943317,0.0001260369,0.00009180834,0.002668098],"study_design_scores_gemma":[0.0000896608,0.0004749932,0.0748535,0.00003374706,0.00005887701,0.00371038,0.00008818928,0.002867006,0.9055002,0.0002599042,0.01204268,0.00002092581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942552,0.001307528,0.002908176,0.0001249261,0.00002900143,0.00003184778,0.0004338364,0.00004284974,0.0008665412],"genre_scores_gemma":[0.992888,0.0008287696,0.003377277,0.0001002098,0.00001469745,0.00002410634,0.001165496,0.00001399192,0.001587312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001160099,"threshold_uncertainty_score":0.003880858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01037858154244876,"score_gpt":0.2333976842318176,"score_spread":0.2230191026893689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}