{"id":"W1995584427","doi":"10.1021/bi0495230","title":"Transmembrane Helix 11 of Multidrug Resistance Protein 1 (MRP1/ABCC1):  Identification of Polar Amino Acids Important for Substrate Specificity and Binding of ATP at Nucleotide Binding Domain 1","year":2004,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Transmembrane domain; ATP-binding cassette transporter; ABCC1; Cyclic nucleotide-binding domain; Biochemistry; Transmembrane protein; Mutagenesis; Transport protein; Amino acid; Protein structure; Chemistry; Biology; Biophysics; Mutation; Transporter; Nucleotide; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004968051,0.0002385776,0.0005564328,0.00009985747,0.00008488328,0.000007208946,0.0001443675,0.000192397,0.00001707389],"category_scores_gemma":[0.00003801969,0.0002252801,0.0002018575,0.0002393954,0.0002644893,0.00006206909,0.00001335449,0.0001087836,6.144302e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001104471,"about_ca_system_score_gemma":0.0001222893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002756285,"about_ca_topic_score_gemma":0.0000617996,"domain_scores_codex":[0.9978639,0.00001162001,0.00104824,0.0004248349,0.0003671404,0.0002842514],"domain_scores_gemma":[0.998647,0.00002705261,0.0006478375,0.000399272,0.0001527102,0.0001261237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008461889,0.000213006,0.005801477,0.004762574,0.0000639833,0.00001564021,0.0004982882,0.000001727782,0.9874745,0.0002925166,0.000004752552,0.00002532562],"study_design_scores_gemma":[0.002638962,0.00006464218,0.005132818,0.001104067,0.0001105157,0.000007900085,0.00069141,0.000006911679,0.9898229,0.0001592876,0.0000679849,0.0001925677],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968684,0.000569188,0.0007607055,0.0001637332,0.00005285713,0.0008282282,0.0006469713,0.00002914222,0.0000807683],"genre_scores_gemma":[0.9920492,0.0001027058,0.006468195,0.000003578827,0.0000440724,0.00002887881,0.0002140055,0.00003796687,0.001051392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00570749,"threshold_uncertainty_score":0.9186655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01037858154244876,"score_gpt":0.2333976842318176,"score_spread":0.2230191026893689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}