{"id":"W1995610816","doi":"10.1016/j.bmc.2008.05.066","title":"Selective angiotensin II AT2 receptor agonists: Benzamide structure–activity relationships","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Canada Research Chairs; Stiftelsen för Strategisk Forskning","keywords":"Chemistry; Benzamide; Agonist; Receptor; Selectivity; Stereochemistry; Carboxamide; Chemical synthesis; Partial agonist; Substituent; Structure–activity relationship; Functional selectivity; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002353788,0.0003434937,0.0003152005,0.00003215112,0.0006760365,0.00001467549,0.0002738221,0.0004985634,0.000742471],"category_scores_gemma":[0.0004183567,0.0003275296,0.0001454022,0.0002495466,0.0002051185,0.00001010767,0.0001415823,0.0005176718,0.00001707542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000113869,"about_ca_system_score_gemma":0.0003355251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005052184,"about_ca_topic_score_gemma":0.000009555092,"domain_scores_codex":[0.9981378,0.00007914219,0.0003137802,0.0006655204,0.0003647576,0.0004390116],"domain_scores_gemma":[0.9988573,0.00002468271,0.0001938868,0.0004722773,0.0001974271,0.0002543918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001125837,0.00006447919,0.0007936874,0.00002215595,0.00008669503,0.00001048963,0.0001657493,0.000004172649,0.9924768,0.000009378467,0.005925986,0.0003278494],"study_design_scores_gemma":[0.0005903363,0.0001919061,0.003118881,0.00003466268,0.00003739011,0.0002481274,0.0001370931,0.00002227304,0.9847471,0.00007344895,0.01042868,0.000370169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961957,0.00107623,0.001049067,0.0003500201,0.0002842713,0.0001639669,0.00005191167,0.00005742271,0.0007714162],"genre_scores_gemma":[0.9950511,0.0001692328,0.001155991,0.0001677892,0.001350724,0.000008212412,0.0002423214,0.00005576175,0.001798836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007729737,"threshold_uncertainty_score":0.9999177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01749437952368362,"score_gpt":0.2218447784154295,"score_spread":0.2043503988917459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}