{"id":"W1995610816","doi":"10.1016/j.bmc.2008.05.066","title":"Selective angiotensin II AT2 receptor agonists: Benzamide structure–activity relationships","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Canada Research Chairs; Stiftelsen för Strategisk Forskning","keywords":"Chemistry; Benzamide; Agonist; Receptor; Selectivity; Stereochemistry; Carboxamide; Chemical synthesis; Partial agonist; Substituent; Structure–activity relationship; Functional selectivity; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003090297,0.0004857268,0.0004161159,0.0002459152,0.0001274402,0.0003634591,0.0003046839,0.0002151055,0.003274445],"category_scores_gemma":[0.0002805644,0.000194115,0.0001850199,0.0002325593,0.0001760455,0.0003378796,0.00014766,0.0005941893,0.0007286616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003398428,"about_ca_system_score_gemma":0.0001994851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009573291,"about_ca_topic_score_gemma":0.003339171,"domain_scores_codex":[0.9999,0.00002931578,0.000006019704,0.00001156468,0.00002182065,0.00003122617],"domain_scores_gemma":[0.9998875,0.00004016181,0.00003132865,0.000005530721,0.00001517416,0.00002033391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002773437,0.0006680345,0.0007628848,0.0004447971,0.00008368576,0.0002569652,0.00005674284,0.001689596,0.9430631,0.001333199,0.001503765,0.0473637],"study_design_scores_gemma":[0.001483994,0.02456896,0.02117776,0.000109892,0.0007589502,0.002257072,0.0001212922,0.006370814,0.9035853,0.001294552,0.03815421,0.0001171395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8761961,0.0861523,0.009438492,0.001489162,0.0002446106,0.0002416084,0.001346846,0.0002799691,0.02461089],"genre_scores_gemma":[0.943782,0.04551008,0.002793795,0.0005923311,0.0001564729,0.00006322477,0.0008419857,0.00002071648,0.006239376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003274445,"threshold_uncertainty_score":0.01095408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01749437952368362,"score_gpt":0.2218447784154295,"score_spread":0.2043503988917459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}