{"id":"W1995692151","doi":"10.1016/j.cell.2011.11.024","title":"Correction of Both NBD1 Energetics and Domain Interface Is Required to Restore ΔF508 CFTR Folding and Function","year":2012,"lang":"en","type":"article","venue":"Cell","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":291,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research","keywords":"Cystic fibrosis transmembrane conductance regulator; ΔF508; Biogenesis; Cyclic nucleotide-binding domain; Endoplasmic reticulum; Biology; Folding (DSP implementation); Protein folding; Transmembrane domain; Mutation; Cell biology; Cystic fibrosis; Biophysics; Biochemistry; Genetics; Membrane; Peptide sequence; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836872,0.00007822429,0.0001487963,0.00008653877,0.00003980897,0.000009237313,0.00002434401,0.0000462687,0.00004233406],"category_scores_gemma":[0.0001571728,0.00006954463,0.00001767042,0.0001161925,0.00006247948,0.0001073659,0.00005629626,0.00008260948,0.000007245614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005091458,"about_ca_system_score_gemma":0.00001664818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004528983,"about_ca_topic_score_gemma":0.000009887195,"domain_scores_codex":[0.9993254,0.00002856474,0.0001389593,0.0001442872,0.0001697093,0.0001930603],"domain_scores_gemma":[0.9994791,0.0001010726,0.0000461882,0.0001403455,0.00004848313,0.0001848248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005655813,0.00005631512,0.014737,0.0001817987,0.00001237905,9.622689e-7,0.001293565,0.000007747924,0.9570083,0.00001943894,0.01719421,0.008922716],"study_design_scores_gemma":[0.001679044,0.001747654,0.0850869,0.0004087394,0.00008693188,0.00003474825,0.002021444,0.000811289,0.7688386,0.0001315761,0.138957,0.0001961269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876812,0.003340687,0.006479326,0.0001660075,0.0005414986,0.0001911022,0.000003147751,0.00001895506,0.001578151],"genre_scores_gemma":[0.9919119,0.0001447232,0.004220638,0.00006218302,0.0001297264,0.000006470504,0.000003091365,0.00001388645,0.003507423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1881697,"threshold_uncertainty_score":0.2835948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01882538341714529,"score_gpt":0.2964290105790396,"score_spread":0.2776036271618944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}