{"id":"W1995720888","doi":"10.1038/mi.2015.27","title":"Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2","year":2015,"lang":"en","type":"article","venue":"Mucosal Immunology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates","keywords":"Defensin; Mucin; Mucin 2; Microbiology; Antimicrobial peptides; Proinflammatory cytokine; Beta defensin; Antimicrobial; Biology; Immunology; Gene expression; Biochemistry; Inflammation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001131395,0.000318163,0.000187271,0.0002452528,0.000133745,0.0004082248,0.00007979596,0.0002219122,0.001046231],"category_scores_gemma":[0.0001396501,0.0001469973,0.000204883,0.0001148536,0.0001629282,0.0002587916,0.0002454811,0.0003430367,0.0002274949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002429304,"about_ca_system_score_gemma":0.0001533428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004829045,"about_ca_topic_score_gemma":0.0005330586,"domain_scores_codex":[0.99991,0.00001490238,0.000005824159,0.00001926512,0.00002192346,0.00002807697],"domain_scores_gemma":[0.9998665,0.00001075283,0.00003869598,0.00001309211,0.0000234488,0.00004747388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005629416,0.000002259806,0.0002632946,0.00001263779,0.000001372283,0.00003143316,0.000006284012,0.00001174828,0.999248,0.00002548015,0.000009953895,0.0003311423],"study_design_scores_gemma":[0.00002668552,0.000423995,0.05639368,0.00002178065,0.00002433933,0.0007623645,0.0001361641,0.001100125,0.9367668,0.00009818166,0.004235642,0.00001020028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937611,0.00313073,0.001765256,0.000096565,0.00001895331,0.00001189293,0.0001439365,0.00004794267,0.00102356],"genre_scores_gemma":[0.9967378,0.0007243106,0.001047394,0.00004226067,0.00000979191,0.000009432004,0.0001871289,0.00001459264,0.001227299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001046231,"threshold_uncertainty_score":0.003500044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0183358548361796,"score_gpt":0.231208258650893,"score_spread":0.2128724038147134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}