{"id":"W1995747359","doi":"10.1074/jbc.m606890200","title":"Correction of Apolipoprotein A-I-mediated Lipid Efflux and High Density Lipoprotein Particle Formation in Human Niemann-Pick Type C Disease Fibroblasts","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; University of Alberta","funders":"National Heart, Lung, and Blood Institute","keywords":"NPC1; ABCA1; ABCG1; Liver X receptor; Cholesterol; Endocrinology; Niemann–Pick disease, type C; Internal medicine; Filipin; Agonist; Reverse cholesterol transport; Biology; Apolipoprotein B; Chemistry; Lipoprotein; Biochemistry; Transporter; Receptor; Endosome; Medicine; Nuclear receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003013613,0.0005471527,0.0005388198,0.0003427813,0.0003332041,0.0004880399,0.0003313964,0.0005222418,0.00187531],"category_scores_gemma":[0.0002675731,0.0002538612,0.0004544606,0.0002261908,0.0002713959,0.0001522528,0.0002673309,0.0006111513,0.0006427835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002667588,"about_ca_system_score_gemma":0.0003740676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001890361,"about_ca_topic_score_gemma":0.001615264,"domain_scores_codex":[0.9995714,0.00008475956,0.00008761274,0.00007848837,0.0001236052,0.00005419663],"domain_scores_gemma":[0.9997166,0.00005839168,0.00006676003,0.00006765574,0.00003286873,0.00005772246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000148011,0.00004667675,0.0001053038,0.00003614686,0.00000786389,0.0002507551,0.00002580958,0.00007090007,0.99787,0.0001321084,0.00004681786,0.001259678],"study_design_scores_gemma":[0.00003342531,0.0003651539,0.001679793,0.000005063233,0.00001972291,0.0008603394,0.00003283161,0.0005696216,0.9925389,0.00002847804,0.003858038,0.000008730272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919171,0.001304019,0.003521257,0.0001406044,0.0001240666,0.0001001227,0.000932285,0.0002086113,0.001752018],"genre_scores_gemma":[0.9888333,0.001038086,0.003815023,0.00005614891,0.00001793775,0.0001035946,0.0007994138,0.00005739816,0.005279071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001890361,"threshold_uncertainty_score":0.006273568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01699525820528063,"score_gpt":0.2658226316685113,"score_spread":0.2488273734632307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}