{"id":"W1995773457","doi":"10.1371/journal.pone.0055971","title":"Non-Invasive Imaging of Phosphoinositide-3-Kinase-Catalytic-Subunit-Alpha (PIK3CA) Promoter Modulation in Small Animal Models","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Advanced Centre for Treatment, Research and Education in Cancer; National Cancer Institute; National Institutes of Health; Council of Scientific and Industrial Research, India","keywords":"Bioluminescence imaging; Ovarian cancer; Fusion gene; Reporter gene; Cancer research; Luciferase; Fusion protein; Cell culture; Live cell imaging; Biology; Cisplatin; PI3K/AKT/mTOR pathway; Molecular biology; Transfection; Chemistry; Cell biology; Cell; Cancer; Signal transduction; Gene; Gene expression; Chemotherapy; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001436572,0.0002316681,0.0004853889,0.0002736927,0.00003263155,0.0000215168,0.0001252268,0.0001234555,0.0001171731],"category_scores_gemma":[0.0001050213,0.0002433002,0.00009809594,0.0003525509,0.00008013096,0.0002884029,0.00008395575,0.0003330668,0.00009402094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002367283,"about_ca_system_score_gemma":0.0001879812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009587358,"about_ca_topic_score_gemma":0.00008470647,"domain_scores_codex":[0.9983069,0.0000288621,0.0004816498,0.0004042941,0.0003938226,0.0003844989],"domain_scores_gemma":[0.9987506,0.00004456109,0.0001739976,0.000513249,0.0003637862,0.0001538463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000173757,0.001528759,0.01463964,0.000461184,0.0001888526,0.00008700912,0.0009757763,0.0003492077,0.9799568,0.00008004665,0.0000757907,0.001483156],"study_design_scores_gemma":[0.002325642,0.0003101279,0.03398049,0.00151409,0.000237551,0.00001702993,0.00009047444,0.1929471,0.7675863,0.0007489802,0.00000136365,0.0002409127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993951,0.000305956,0.0009248549,0.000671556,0.00002990039,0.001611911,0.00001595023,0.00006659955,0.002422284],"genre_scores_gemma":[0.9947932,0.00004573565,0.004445992,0.000199938,0.00006896453,0.00013864,0.00009771048,0.00006892603,0.0001409176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2123705,"threshold_uncertainty_score":0.9921494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03533928085019759,"score_gpt":0.2175593817502692,"score_spread":0.1822201009000716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}