{"id":"W1995781028","doi":"10.1002/pro.285","title":"The importance of valine 114 in ligand binding in β<sub>2</sub>‐adrenergic receptor","year":2009,"lang":"en","type":"article","venue":"Protein Science","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"U.S. National Library of Medicine; Canadian Institutes of Health Research; Manitoba Medical Service Foundation; Manitoba Health Research Council; University of Pittsburgh; Heart and Stroke Foundation of Canada; National Institutes of Health; National Science Foundation","keywords":"G protein-coupled receptor; Ligand (biochemistry); Chemistry; Receptor; Stereochemistry; Binding site; Amino acid; Agonist; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001319062,0.00009313341,0.0001085642,0.00007937764,0.00009808147,0.0000320915,0.0003747511,0.0000590083,0.000003473665],"category_scores_gemma":[0.0002208496,0.00006958673,0.00003324795,0.0005511537,0.000150223,0.00001072549,0.00006294595,0.0000842963,0.000002450437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000024041,"about_ca_system_score_gemma":0.0001247033,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007859758,"about_ca_topic_score_gemma":0.00005379488,"domain_scores_codex":[0.9988556,0.00003187542,0.0002757746,0.0003156886,0.0002255359,0.0002955337],"domain_scores_gemma":[0.999535,0.000008976826,0.0001134052,0.0002384837,0.00005668246,0.00004745646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002595386,0.00002143288,0.001126487,0.000002933664,7.517778e-7,9.944503e-7,0.00003071823,0.00008179515,0.9924948,0.0003242191,0.000007017562,0.005882881],"study_design_scores_gemma":[0.0001951764,0.0001714055,0.0009398449,0.00004596794,6.339617e-7,0.000001346844,0.00004044086,0.0001633122,0.9975343,0.0005954767,0.000218637,0.00009342893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998459,0.0007362744,0.0001899988,0.0001546272,0.00006836874,0.0002366004,0.000001883419,0.000003662383,0.0001495667],"genre_scores_gemma":[0.9988579,0.0001997213,0.0007914139,0.00004764105,0.00004276395,0.00001882525,0.000003114179,0.000005043229,0.00003353648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005789452,"threshold_uncertainty_score":0.2837665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008525265996558427,"score_gpt":0.2441149257983662,"score_spread":0.2355896598018078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}