{"id":"W1995781028","doi":"10.1002/pro.285","title":"The importance of valine 114 in ligand binding in β<sub>2</sub>‐adrenergic receptor","year":2009,"lang":"en","type":"article","venue":"Protein Science","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"U.S. National Library of Medicine; Canadian Institutes of Health Research; Manitoba Medical Service Foundation; Manitoba Health Research Council; University of Pittsburgh; Heart and Stroke Foundation of Canada; National Institutes of Health; National Science Foundation","keywords":"G protein-coupled receptor; Ligand (biochemistry); Chemistry; Receptor; Stereochemistry; Binding site; Amino acid; Agonist; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001997463,0.0004463371,0.000342739,0.0001323819,0.0002057138,0.0004413741,0.0004245271,0.0004811186,0.0006776972],"category_scores_gemma":[0.0003044144,0.0001829794,0.0004736249,0.0001242994,0.0003780152,0.0002639483,0.0002800676,0.0005894085,0.0003280159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003048887,"about_ca_system_score_gemma":0.0002077466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006960469,"about_ca_topic_score_gemma":0.0005448706,"domain_scores_codex":[0.9998307,0.00004704919,0.00002375512,0.00003709598,0.00003272438,0.00002857013],"domain_scores_gemma":[0.9998092,0.00004850055,0.00008166089,0.00001281553,0.00001627305,0.00003154273],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007207957,0.00006886403,0.002150085,0.0001418695,0.0000568109,0.0009942708,0.00006786923,0.001567073,0.9902001,0.0006842689,0.00007894863,0.003269056],"study_design_scores_gemma":[0.0001237135,0.0009427422,0.01441141,0.00005592019,0.000211903,0.002290105,0.0001442137,0.006780374,0.9686946,0.0004300854,0.005859246,0.00005570824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963205,0.001105827,0.001748867,0.00007398257,0.00005724792,0.00001726846,0.00007690417,0.00002981678,0.0005696301],"genre_scores_gemma":[0.9973395,0.0004442677,0.001342332,0.00008845152,0.00001308756,0.00001244297,0.0001331893,0.00001781357,0.0006088833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006960469,"threshold_uncertainty_score":0.002267122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008525265996558427,"score_gpt":0.2441149257983662,"score_spread":0.2355896598018078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}