{"id":"W1995823730","doi":"10.1038/sj.bjp.0705252","title":"Development of agonists of endothelin‐1 exhibiting selectivity towards ET<sub>A</sub> receptors","year":2003,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"","keywords":"Receptor; Agonist; Pharmacophore; Bicyclic molecule; Peptide; Guinea pig; Endothelin receptor; Stereochemistry; Chemistry; Endothelins; Biological activity; Structure–activity relationship; Pharmacology; Biochemistry; Biology; In vitro; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002719292,0.0004333367,0.0004110591,0.0001885737,0.0001135972,0.0002530866,0.00047062,0.0003823976,0.002081619],"category_scores_gemma":[0.0002002226,0.000207889,0.0002341099,0.0001857673,0.0001074581,0.0002580972,0.0002695591,0.0006994058,0.0009292331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001768797,"about_ca_system_score_gemma":0.0001767606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000140274,"about_ca_topic_score_gemma":0.0003354122,"domain_scores_codex":[0.9998486,0.00003926535,0.00001999504,0.00002415322,0.000032508,0.00003543275],"domain_scores_gemma":[0.9999021,0.00002451686,0.0000163298,0.000007949105,0.00001852945,0.00003057677],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003289885,0.0001393631,0.00009399268,0.0001635107,0.00001377228,0.0001272021,0.0000295324,0.0002201975,0.9925668,0.0001941064,0.0001081547,0.006014485],"study_design_scores_gemma":[0.0003532656,0.006632175,0.002438093,0.0000468344,0.0001064188,0.001019308,0.00004893102,0.001035617,0.9661946,0.0001353617,0.02195801,0.0000314749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9644806,0.01937252,0.008266722,0.0002291182,0.0001900244,0.0004573228,0.0007880178,0.0001328653,0.006082734],"genre_scores_gemma":[0.9542278,0.01822437,0.01847796,0.0005381944,0.0001399194,0.0004104847,0.001801144,0.00004512829,0.006135059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002081619,"threshold_uncertainty_score":0.00696373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01816447054887632,"score_gpt":0.2996222543412854,"score_spread":0.281457783792409,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}