{"id":"W1995828394","doi":"10.1074/jbc.m706257200","title":"A Sensitive Flow Cytometry-based Nucleotide Excision Repair Assay Unexpectedly Reveals That Mitogen-activated Protein Kinase Signaling Does Not Regulate the Removal of UV-induced DNA Damage in Human Cells","year":2007,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Skin Protection and Aging","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"National Cancer Institute","keywords":"Flow cytometry; Protein kinase A; DNA damage; Cell biology; Nucleotide excision repair; DNA; DNA repair; Mitogen-activated protein kinase; Chemistry; Nucleotide; Molecular biology; Kinase; Biology; Cancer research; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003064206,0.0002486913,0.0006181105,0.0001674144,0.0001142709,0.00001953408,0.0001710098,0.0003383104,0.0001288623],"category_scores_gemma":[0.001293436,0.0001329638,0.0003791208,0.0005426924,0.0001563938,0.00005945074,0.00005517434,0.0009559133,9.557525e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002015953,"about_ca_system_score_gemma":0.0000745263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001356947,"about_ca_topic_score_gemma":0.00000101058,"domain_scores_codex":[0.9976328,0.0002763354,0.0009565289,0.0003069903,0.0004918657,0.0003354636],"domain_scores_gemma":[0.9978246,0.0004598268,0.0009021313,0.0002954549,0.0003379128,0.0001800383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001859127,0.0002028337,0.0008762693,0.0000905716,0.00006538984,0.002045313,0.0001131488,0.00002432104,0.9940888,0.000001126773,0.00001646463,0.0006166079],"study_design_scores_gemma":[0.001874508,0.0002902251,0.009821761,0.001090065,0.000036517,0.0003214847,0.0007562889,0.0001457611,0.9853989,0.00004469306,0.00005192933,0.000167805],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982879,0.00004002902,0.0004965118,0.0003865167,0.00009087116,0.0003702247,0.000006233285,0.00005011709,0.000271667],"genre_scores_gemma":[0.9961574,0.000003392418,0.003128196,0.0001913584,0.000290087,0.000002889783,0.000006317876,0.00001934293,0.0002009877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008945492,"threshold_uncertainty_score":0.5422106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03374313008673188,"score_gpt":0.2868554932197361,"score_spread":0.2531123631330042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}