{"id":"W1995864039","doi":"10.1016/j.cgh.2008.06.007","title":"Treatment of Active Crohn's Disease With MLN0002, a Humanized Antibody to the α4β7 Integrin","year":2008,"lang":"en","type":"article","venue":"Clinical Gastroenterology and Hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":285,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; London Health Sciences Centre; Hôpital du Saint-Sacrement; Hôtel-Dieu de Québec; McGill University; University of Toronto; Mount Sinai Hospital; St. Michael's Hospital; Western University; University of Alberta; Robarts Clinical Trials","funders":"","keywords":"Medicine; Clinical endpoint; Placebo; Internal medicine; Adverse effect; Gastroenterology; Crohn's disease; Inflammatory bowel disease; Clinical trial; Antibody; Immunology; Randomized controlled trial; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002553979,0.0003147835,0.0006721641,0.0002584989,0.0002264527,0.0002583927,0.0002448658,0.0004711833,0.0009904366],"category_scores_gemma":[0.0002403805,0.00009578184,0.0003550932,0.0002104452,0.0002059946,0.0001897536,0.0001823117,0.0008543444,0.000261273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002127285,"about_ca_system_score_gemma":0.0001964218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004858092,"about_ca_topic_score_gemma":0.001004603,"domain_scores_codex":[0.9999008,0.00002700366,0.00000597492,0.000009943638,0.00002280232,0.00003346482],"domain_scores_gemma":[0.9999524,0.00001053198,0.000005888355,0.000004253448,0.000003675829,0.0000231964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.02586954,0.006373407,0.00537985,0.0006197082,0.0003132071,0.002626018,0.0002333686,0.001329476,0.6524717,0.0006718245,0.005319391,0.2987926],"study_design_scores_gemma":[0.06507095,0.2271869,0.1109573,0.000250491,0.0007175373,0.01758967,0.0003731093,0.01015243,0.4449852,0.001074791,0.1214803,0.0001613684],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798985,0.01251199,0.001393471,0.000832418,0.0003254108,0.0001753805,0.0001463044,0.0001540659,0.004562423],"genre_scores_gemma":[0.9915039,0.003610066,0.0009567229,0.0003684698,0.000107372,0.00008606796,0.0004287229,0.0000127982,0.002925883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009904366,"threshold_uncertainty_score":0.003313363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02265825855705442,"score_gpt":0.3154200160267716,"score_spread":0.2927617574697171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}