{"id":"W1995875761","doi":"10.1371/journal.pone.0040342","title":"Dose Dependent Effects on Cell Cycle Checkpoints and DNA Repair by Bendamustine","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; National Cancer Institute","keywords":"Mitosis; Bendamustine; DNA damage; G2-M DNA damage checkpoint; Cell cycle; CHEK1; Biology; HeLa; Cell biology; Cell cycle checkpoint; DNA repair; DNA; Cell; Cancer research; Chemistry; Leukemia; Genetics; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000122317,0.0003838441,0.0003068887,0.0002550718,0.0001355221,0.0002157315,0.0002209672,0.0003509955,0.002000572],"category_scores_gemma":[0.0002288872,0.0002158238,0.000270266,0.0002334421,0.00017656,0.0002046097,0.000186132,0.0006342527,0.0003083034],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003469832,"about_ca_system_score_gemma":0.000175817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007567839,"about_ca_topic_score_gemma":0.001512037,"domain_scores_codex":[0.9998353,0.00003595224,0.00002009157,0.00003860399,0.00004015577,0.0000298807],"domain_scores_gemma":[0.9998152,0.00006652046,0.00003692886,0.00002288978,0.00003417671,0.00002435078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003140346,0.00005434081,0.0001281889,0.00004825674,0.000008992287,0.0000164766,0.00001986034,0.0001127206,0.9977246,0.00003756168,0.00006033801,0.001474578],"study_design_scores_gemma":[0.00001968334,0.000911677,0.003773642,0.000007108182,0.00001254892,0.000055778,0.00001335885,0.0002987417,0.9935012,0.00002719118,0.001372304,0.000006757539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858407,0.007127627,0.001801525,0.0002150565,0.00008313905,0.00009857681,0.001105046,0.0001167031,0.00361182],"genre_scores_gemma":[0.9876995,0.002608702,0.002224407,0.0002011911,0.00002604946,0.0001293866,0.0014855,0.00005257531,0.005572641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002000572,"threshold_uncertainty_score":0.006692588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0101936104360305,"score_gpt":0.2056529862484037,"score_spread":0.1954593758123732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}