{"id":"W1995907801","doi":"10.1021/jm020441o","title":"Synthesis and Dopamine Receptor Modulating Activity of 3-Substituted γ-Lactam Peptidomimetics of l-Prolyl-l-leucyl-glycinamide","year":2003,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Chemistry; Peptidomimetic; Substituent; Stereochemistry; Moiety; Lactam; Dopamine; Receptor; Residue (chemistry); Structure–activity relationship; In vitro; Biochemistry; Peptide","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009678183,0.0003329592,0.0009084045,0.00008091776,0.0000665552,0.00001596435,0.0003188837,0.0003509606,0.00003774344],"category_scores_gemma":[0.0110065,0.0002808224,0.0003900142,0.0002542073,0.0003441335,0.00001758941,0.0000873399,0.0003878821,6.613893e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004681845,"about_ca_system_score_gemma":0.0001743371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001206091,"about_ca_topic_score_gemma":0.000001411991,"domain_scores_codex":[0.9976386,0.0001036979,0.0009478644,0.0003489207,0.0006065202,0.0003543242],"domain_scores_gemma":[0.9967073,0.0007776952,0.001388991,0.0003704086,0.0004372815,0.0003183747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005356589,0.0002447719,0.003979454,0.0003711547,0.0003937845,0.00001156793,0.0000561833,0.00004855434,0.9923685,0.000004371232,0.000538566,0.001929516],"study_design_scores_gemma":[0.0008896268,0.0001554268,0.0009157074,0.0003423407,0.0004422601,0.0001691988,0.000752457,0.0001219124,0.9931611,0.00003098373,0.002939161,0.00007977099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994632,0.002358757,0.000596464,0.00005600528,0.00007050976,0.0000678255,0.00002521803,0.000004980069,0.002188234],"genre_scores_gemma":[0.9960404,0.0009975916,0.002119038,0.00001891042,0.0003716697,0.00000366844,0.000009509739,0.00003289164,0.0004063139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01003868,"threshold_uncertainty_score":0.9999644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008855188052687247,"score_gpt":0.2299955690729553,"score_spread":0.2211403810202681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}