{"id":"W1995922001","doi":"10.1158/1538-7445.am2013-86","title":"Abstract 86: Prolactin and testosterone induction of carboxypeptidase-D to promote cell survival is greater in prostate cancer cells than benign prostate cells, and their synergistic action in prostate cancer cells is effectively blocked by receptor antagonists Δ1-9-G129R and flutamide.","year":2013,"lang":"en","type":"article","venue":"Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"LNCaP; Prostate cancer; Prostate; Endocrinology; Androgen receptor; Prolactin; Downregulation and upregulation; Cancer research; Internal medicine; PCA3; Testosterone (patch); Receptor; Cell culture; Chemistry; Biology; Medicine; Cancer; Hormone; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001134751,0.0004587921,0.0003698275,0.0002566448,0.0001706156,0.0003189356,0.0001651124,0.0001888518,0.006843613],"category_scores_gemma":[0.00008608335,0.000177092,0.0005105591,0.0002895882,0.0001839962,0.0001308171,0.0002428618,0.000687587,0.001597514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002638497,"about_ca_system_score_gemma":0.0003789869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001114442,"about_ca_topic_score_gemma":0.001396534,"domain_scores_codex":[0.999805,0.00002320271,0.00002044836,0.00004240608,0.0000588986,0.00005001797],"domain_scores_gemma":[0.9998866,0.00001539982,0.00002407891,0.00001109042,0.00001368953,0.00004902844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003776671,0.00005855902,0.000180523,0.00008595519,0.000007781547,0.00006503466,0.000008259567,0.00001566213,0.9971426,0.00003806618,0.0002373831,0.001782532],"study_design_scores_gemma":[0.00009159199,0.001184426,0.02076704,0.00001137312,0.00003684182,0.0008192272,0.00005115546,0.0003685178,0.9688604,0.00003061544,0.007770736,0.000008098393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.970695,0.008670421,0.004454352,0.0006685439,0.0003847691,0.00009342223,0.006462215,0.0004157823,0.008155623],"genre_scores_gemma":[0.9712448,0.00273419,0.002835265,0.0002283051,0.00008439743,0.0001026622,0.006067014,0.0000629172,0.0166404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006843613,"threshold_uncertainty_score":0.0228942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03749523915747602,"score_gpt":0.3347341387463266,"score_spread":0.2972388995888506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}