{"id":"W1995947612","doi":"10.1242/dev.067058","title":"Ectopic retinoic acid signaling affects outflow tract cushion development through suppression of the myocardial Tbx2-Tgfβ2 pathway","year":2011,"lang":"en","type":"article","venue":"Development","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Japan Society for the Promotion of Science; Nara Medical University","keywords":"Retinoic acid; Downregulation and upregulation; Biology; Ectopic expression; TBX1; Phenotype; Transforming growth factor; Transcription factor; Signal transduction; Heart development; Cell biology; Tretinoin; Cancer research; Retinoic acid receptor; Internal medicine; Gene; Genetics; Gene expression; Medicine; Embryonic stem cell; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001511432,0.0003790144,0.0002648073,0.0002600027,0.0001864912,0.0003317938,0.0002029053,0.0002617677,0.001023078],"category_scores_gemma":[0.0000804575,0.0002243971,0.0002924825,0.0001233821,0.0002911873,0.0001751123,0.0002285332,0.0005941849,0.0002977194],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002115632,"about_ca_system_score_gemma":0.0002625155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000743958,"about_ca_topic_score_gemma":0.0008160931,"domain_scores_codex":[0.9998121,0.00003349726,0.00002680763,0.00004404686,0.00003550817,0.00004808348],"domain_scores_gemma":[0.9998858,0.00001341019,0.00003873047,0.00001347101,0.00000773418,0.0000408807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004560584,0.000005294143,0.00007833319,0.00001031994,0.000002011397,0.00004161962,0.000009862833,0.00001890713,0.9994892,0.00005164287,0.00000670829,0.0002403957],"study_design_scores_gemma":[0.00002100487,0.0001394299,0.002632456,0.000004719589,0.00001991236,0.0002135935,0.0000398985,0.0007492596,0.994436,0.00003865236,0.001701116,0.000003855691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935567,0.001868543,0.002544277,0.0001167678,0.00003821022,0.00001773673,0.0002009142,0.00008588328,0.001570923],"genre_scores_gemma":[0.9945108,0.001011457,0.001395325,0.0000421459,0.00001032035,0.00002723283,0.0001734452,0.0000227802,0.002806521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001023078,"threshold_uncertainty_score":0.003422558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03302243109424795,"score_gpt":0.2570805422321742,"score_spread":0.2240581111379263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}