{"id":"W1995989459","doi":"10.1371/journal.pone.0122111","title":"Effects of the I559P gp41 Change on the Conformation and Function of the Human Immunodeficiency Virus (HIV-1) Membrane Envelope Glycoprotein Trimer","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Gp41; Ectodomain; Glycoprotein; Trimer; Viral envelope; Chemistry; Biology; Virology; Transmembrane protein; Conformational change; Antibody; Biochemistry; Molecular biology; Epitope; Receptor; Dimer; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002078177,0.0003990523,0.0001985396,0.0001151451,0.0001965601,0.0003083851,0.0002904423,0.0005021768,0.001598238],"category_scores_gemma":[0.0003408488,0.0001613404,0.0003075706,0.000100216,0.000327898,0.0002116515,0.000179015,0.0005278579,0.0002606435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002441076,"about_ca_system_score_gemma":0.0001661104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001109065,"about_ca_topic_score_gemma":0.0004988346,"domain_scores_codex":[0.9998337,0.00004373426,0.00001884894,0.00003458929,0.00002473877,0.00004433875],"domain_scores_gemma":[0.9998504,0.0000432833,0.00003930019,0.00001516193,0.0000147801,0.00003707417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001887432,0.0003912801,0.0004610173,0.00004689715,0.00004464071,0.0003377194,0.00004446362,0.0002743956,0.9937943,0.0001971091,0.00009307641,0.002427644],"study_design_scores_gemma":[0.0001801535,0.004773172,0.006143556,0.00001734649,0.00008747502,0.0006758869,0.00007156799,0.00165608,0.9847594,0.00007888147,0.001534623,0.00002177415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999108,0.0002599573,0.0001051184,0.0000337237,0.00001997838,0.000007998143,0.00003589838,0.000009164705,0.0004201219],"genre_scores_gemma":[0.9990872,0.0002151153,0.0001789913,0.00006134235,0.000008694605,0.000005087451,0.00007524133,0.00000981165,0.0003584675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001598238,"threshold_uncertainty_score":0.005346656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05665623859649286,"score_gpt":0.2352273468686298,"score_spread":0.1785711082721369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}