{"id":"W1996032846","doi":"10.1182/blood-2011-11-392951","title":"Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":509,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; University of California, San Francisco; Center for AIDS Research, University of Washington; National Institutes of Health; Cancer Research Institute","keywords":"Interleukin 21; CD16; Lymphokine-activated killer cell; Interleukin 12; Biology; Janus kinase 3; NK-92; CD49b; NKG2D; Cell biology; Natural killer cell; Cytotoxic T cell; Cytotoxicity; Immunology; Molecular biology; T cell; Immune system; CD3; CD8; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001740721,0.0002553098,0.0001551378,0.000240304,0.0001971203,0.0004589982,0.0002099908,0.0002858592,0.002964356],"category_scores_gemma":[0.0001871196,0.00007684698,0.0002217923,0.0002458847,0.0002665058,0.0002888148,0.0003885944,0.0005038148,0.001044264],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006302468,"about_ca_system_score_gemma":0.0002685558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004967919,"about_ca_topic_score_gemma":0.0004521775,"domain_scores_codex":[0.9998192,0.00003588237,0.00001018877,0.00003061546,0.00003953133,0.00006462462],"domain_scores_gemma":[0.9999467,0.000005354265,0.00001363756,0.000008218431,0.00001219651,0.00001393172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005797623,0.00002404205,0.0009867498,0.00007790531,0.000009751067,0.000148647,0.00005400013,0.0001060219,0.9856876,0.001272534,0.0005422261,0.01051079],"study_design_scores_gemma":[0.00002536872,0.0002062937,0.01084251,0.00001818982,0.00002395512,0.0008507365,0.00006199876,0.001052777,0.9557161,0.0004976757,0.03069525,0.000009040907],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9587221,0.009920524,0.01181623,0.0004909807,0.0002064169,0.0001199359,0.001109698,0.0005222539,0.01709198],"genre_scores_gemma":[0.9894953,0.00169271,0.002085322,0.0001455367,0.00003370359,0.00004985516,0.0007594866,0.00004546209,0.005692655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002964356,"threshold_uncertainty_score":0.009916723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005801116320952233,"score_gpt":0.2106082468209214,"score_spread":0.2048071304999691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}