{"id":"W1996032846","doi":"10.1182/blood-2011-11-392951","title":"Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":509,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; University of California, San Francisco; Center for AIDS Research, University of Washington; National Institutes of Health; Cancer Research Institute","keywords":"Interleukin 21; CD16; Lymphokine-activated killer cell; Interleukin 12; Biology; Janus kinase 3; NK-92; CD49b; NKG2D; Cell biology; Natural killer cell; Cytotoxic T cell; Cytotoxicity; Immunology; Molecular biology; T cell; Immune system; CD3; CD8; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009653952,0.0001435057,0.0001703289,0.00004580062,0.0001781909,0.00001217855,0.00008989101,0.000264814,0.0006742704],"category_scores_gemma":[0.00001359492,0.0001172252,0.00003767368,0.00005475385,0.0001061315,0.00008931416,0.00006506571,0.000263161,0.0001569635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000905137,"about_ca_system_score_gemma":0.00001353081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005542226,"about_ca_topic_score_gemma":0.0000250748,"domain_scores_codex":[0.9991724,0.0001123959,0.0001505552,0.0001888272,0.00001876509,0.0003570144],"domain_scores_gemma":[0.9996659,0.00005976233,0.00007541998,0.0001443828,0.00002591839,0.00002863872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003927031,0.0002874333,0.02029369,0.00002157742,0.00003984506,9.884949e-7,0.0002171872,5.761122e-8,0.973938,0.00004809284,0.005048353,0.00006549525],"study_design_scores_gemma":[0.002062911,0.0001467885,0.1392431,0.000005768453,0.00007197276,0.00006303311,0.00008917958,4.372774e-7,0.8416382,0.00001988912,0.01645572,0.0002029517],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860973,0.008507395,0.000003298052,0.00005808093,0.0008993334,0.000141314,0.00001626857,0.00005542913,0.00422162],"genre_scores_gemma":[0.9961639,0.0001063541,0.00003658838,0.0001426462,0.0001065489,0.00001679109,0.000271238,0.000011877,0.003144065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1322998,"threshold_uncertainty_score":0.7382788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005801116320952233,"score_gpt":0.2106082468209214,"score_spread":0.2048071304999691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}