{"id":"W1996081258","doi":"10.1007/s00280-008-0730-x","title":"Population pharmacokinetics of imatinib mesylate and its metabolite in children and young adults","year":2008,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; BC Children's Hospital; Izaak Walton Killam Health Centre","funders":"","keywords":"Imatinib; Imatinib mesylate; Medicine; Pharmacokinetics; NONMEM; Tyrosine-kinase inhibitor; Pharmacology; Population; Myeloid leukemia; Internal medicine; Dosing; Metabolite; Oncology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004266149,0.0001714634,0.0005355602,0.0002200113,0.0001617258,0.0003761704,0.0001098079,0.0002747662,0.0006998415],"category_scores_gemma":[0.001802197,0.0002088224,0.0002806888,0.0002800069,0.0001885014,0.000410533,0.0002209234,0.0005442055,0.0001858345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004330115,"about_ca_system_score_gemma":0.0003771729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00241504,"about_ca_topic_score_gemma":0.002249824,"domain_scores_codex":[0.9997459,0.0000760964,0.00001901211,0.00006043039,0.00005754255,0.00004093497],"domain_scores_gemma":[0.9992901,0.0002806328,0.0001977604,0.00003865833,0.00007389089,0.0001190109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004757598,0.0001531566,0.9642594,0.00005072308,0.0002478219,0.0005147271,0.000610264,0.001002255,0.005946521,0.0002638858,0.0009973694,0.0211961],"study_design_scores_gemma":[0.00007860571,0.001658465,0.9931806,0.000005513269,0.000112665,0.001515668,0.0002981683,0.0008023113,0.001025016,0.0001034443,0.001207269,0.00001226701],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986105,0.0004692725,0.0002047013,0.00003281264,0.000002574036,0.000007108213,0.0002787056,0.00001196548,0.0003822496],"genre_scores_gemma":[0.9987372,0.0003193152,0.0001748994,0.00004023534,0.000009582577,0.00001657035,0.000460353,0.000008368727,0.0002335398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00241504,"threshold_uncertainty_score":0.004801989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01325244747741804,"score_gpt":0.3094661737160925,"score_spread":0.2962137262386745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}