{"id":"W1996083284","doi":"10.1016/j.dnarep.2008.05.005","title":"Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks","year":2008,"lang":"en","type":"article","venue":"DNA repair","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"Terry Fox Research Institute","funders":"National Cancer Institute; Canadian Institutes of Health Research; Stem Cell Network","keywords":"Biology; Ku70; Ku80; Homologous recombination; Embryonic stem cell; DNA damage; Molecular biology; DNA repair; Wortmannin; DNA; DNA-PKcs; Cell biology; Non-homologous end joining; Genetics; Kinase; Gene; DNA-binding protein; Phosphatidylinositol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006699114,0.001032263,0.0008683926,0.001257675,0.0002215938,0.0009902376,0.0006025511,0.0007516888,0.006456188],"category_scores_gemma":[0.0004194079,0.0005915615,0.0006521567,0.0005354249,0.000586005,0.0004689448,0.0004740472,0.001067324,0.002159591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000213636,"about_ca_system_score_gemma":0.0003277839,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005075471,"about_ca_topic_score_gemma":0.0007169563,"domain_scores_codex":[0.9994614,0.00007134874,0.00009647264,0.00009916842,0.000176902,0.00009468557],"domain_scores_gemma":[0.9992619,0.0001525588,0.0002251888,0.0001179998,0.00006356033,0.0001788074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001227993,0.00001610098,0.000235097,0.00004119309,0.00002407901,0.0000899829,0.00001630419,0.00002704948,0.9984471,0.0002090763,0.00005007844,0.000721121],"study_design_scores_gemma":[0.00003336815,0.0001729758,0.005815472,0.00001381839,0.00009748083,0.001442167,0.00003842555,0.0003453989,0.9868374,0.00013951,0.005054621,0.000009130186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799631,0.00475433,0.008579435,0.0002468095,0.0001262072,0.00007101444,0.002502571,0.0005128758,0.00324362],"genre_scores_gemma":[0.9744485,0.002506248,0.005227023,0.0001143728,0.00002462626,0.00007262143,0.006363817,0.0002263298,0.01101647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006456188,"threshold_uncertainty_score":0.0215981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03837066740589431,"score_gpt":0.2684238595056322,"score_spread":0.2300531920997379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}