{"id":"W1996096916","doi":"10.1128/jvi.07133-11","title":"Uncommon Pathways of Immune Escape Attenuate HIV-1 Integrase Replication Capacity","year":2012,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institute on Drug Abuse; Wellcome Trust","keywords":"Integrase; Biology; Viral replication; Allele; Human leukocyte antigen; Integrase inhibitor; Immune system; Genetics; Mutation; Virology; Virus; Gene; Antigen; Viral load; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002539832,0.0002225107,0.0002703049,0.0001076631,0.00009304553,0.0004540737,0.000158632,0.0002601775,0.0009501871],"category_scores_gemma":[0.0004624777,0.00009925121,0.0002429573,0.00009503272,0.0001951965,0.0001517141,0.0002654828,0.0006072382,0.0002089438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002111221,"about_ca_system_score_gemma":0.000120634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002610046,"about_ca_topic_score_gemma":0.0002513617,"domain_scores_codex":[0.9998121,0.00003960947,0.00002096581,0.00003188063,0.00004432967,0.00005120555],"domain_scores_gemma":[0.9996306,0.00008252973,0.0001304805,0.00005597363,0.00002968997,0.00007069376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003189263,0.00008485407,0.01087681,0.00003133203,0.00001719797,0.0002011992,0.00004272541,0.0001558375,0.9819881,0.0001635842,0.0000408842,0.006078572],"study_design_scores_gemma":[0.0002308282,0.005952256,0.2628687,0.00004254196,0.00009753369,0.008777276,0.0002124612,0.008442476,0.709401,0.0006542394,0.003293758,0.00002692341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992124,0.0002163143,0.0002550234,0.00001472953,0.000001452921,0.00000402815,0.0000310368,0.00001445939,0.0002505349],"genre_scores_gemma":[0.9993569,0.00006816599,0.000313914,0.00001903426,0.000002603595,0.000003821246,0.0000524771,0.00000522545,0.0001778843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009501871,"threshold_uncertainty_score":0.003178716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03424121976907417,"score_gpt":0.2705197245886241,"score_spread":0.2362785048195499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}