{"id":"W1996097644","doi":"10.1038/sj.onc.1208875","title":"DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1","year":2005,"lang":"en","type":"article","venue":"Oncogene","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":74,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Aging","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Biology; Pyrimidine dimer; Xeroderma pigmentosum; DNA damage; Phosphatase; Apoptosis; DNA repair; Cockayne syndrome; Kinase; Effector; Cell biology; Nucleotide excision repair; Signal transduction; Molecular biology; c-jun; Gene; DNA; Transcription factor; Phosphorylation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002758945,0.0005406541,0.0002230996,0.0004366916,0.0003117328,0.0004939145,0.0002991927,0.0002800341,0.001712162],"category_scores_gemma":[0.0003137379,0.0002714275,0.0004247712,0.0002063302,0.0003652363,0.0004315239,0.0004487851,0.001074945,0.0006557279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008027515,"about_ca_system_score_gemma":0.0003913907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003224172,"about_ca_topic_score_gemma":0.000654876,"domain_scores_codex":[0.9997281,0.00003801566,0.00001643908,0.00003408677,0.00008617379,0.00009716689],"domain_scores_gemma":[0.9997254,0.00004647035,0.00008145851,0.00003618797,0.00003921358,0.00007115923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006733409,0.00005798892,0.0003933737,0.0000846492,0.00001491607,0.0001271748,0.00002383772,0.0001652223,0.9941124,0.0005562684,0.0001045517,0.003686164],"study_design_scores_gemma":[0.00005383842,0.0002302164,0.005453901,0.00001189949,0.00001867541,0.0003839464,0.00003962507,0.0008110874,0.9907267,0.0005345024,0.001730405,0.000005120904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776505,0.00677761,0.009605356,0.0005573161,0.00008663352,0.00004373724,0.0004362364,0.0001649558,0.004677639],"genre_scores_gemma":[0.9912635,0.002260018,0.00175822,0.00007126849,0.00002868719,0.00002989794,0.000721779,0.00001901438,0.003847583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001712162,"threshold_uncertainty_score":0.005824447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008452731377744651,"score_gpt":0.2238702442050196,"score_spread":0.2154175128272749,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}