{"id":"W1996105414","doi":"10.1111/cbdd.12496","title":"Identification of Novel Proteasome Inhibitors from an Enaminone Library","year":2014,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"University of Tulsa; National Science Foundation","keywords":"Proteasome; Protease; Luciferase; Biochemistry; Chemistry; Small molecule; Lactacystin; Viability assay; Proteolysis; Trypsin; Enzyme; In vitro; Proteasome inhibitor; Transfection","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001080458,0.0005350689,0.0004428111,0.0005212508,0.00013544,0.000326716,0.0003051414,0.0002215896,0.001952332],"category_scores_gemma":[0.0001480434,0.0001665246,0.0002011109,0.0002818518,0.0001147168,0.00022934,0.0001901386,0.0004045228,0.0006565333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002181657,"about_ca_system_score_gemma":0.0002079898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002329707,"about_ca_topic_score_gemma":0.0008504324,"domain_scores_codex":[0.9999282,0.00001012498,0.000006927141,0.00001708718,0.00002210706,0.00001554209],"domain_scores_gemma":[0.9999235,0.00001421974,0.00001469305,0.000008520415,0.0000179167,0.00002129707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001796012,0.0001730733,0.0002778682,0.0001255659,0.00002206348,0.0002689305,0.00002386668,0.000782822,0.9818442,0.0002364323,0.0001643367,0.01590126],"study_design_scores_gemma":[0.000107382,0.001662584,0.002429117,0.0000284663,0.00009424214,0.0009128031,0.00003255561,0.001580117,0.9793169,0.0001101063,0.01370818,0.00001767536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604931,0.007741895,0.01844294,0.0001921789,0.00006533348,0.0006257147,0.001868012,0.0003022096,0.01026848],"genre_scores_gemma":[0.9570248,0.008319354,0.01956305,0.0002117828,0.00004883716,0.0002373941,0.003913745,0.00005042593,0.01063063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001952332,"threshold_uncertainty_score":0.006531179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01454722767127396,"score_gpt":0.240887174482096,"score_spread":0.226339946810822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}