{"id":"W1996105414","doi":"10.1111/cbdd.12496","title":"Identification of Novel Proteasome Inhibitors from an Enaminone Library","year":2014,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"University of Tulsa; National Science Foundation","keywords":"Proteasome; Protease; Luciferase; Biochemistry; Chemistry; Small molecule; Lactacystin; Viability assay; Proteolysis; Trypsin; Enzyme; In vitro; Proteasome inhibitor; Transfection","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003170132,0.0001853832,0.0002254945,0.00003961898,0.00003965427,0.00001505379,0.0003677368,0.0003269798,0.00003795135],"category_scores_gemma":[0.0001838648,0.0001699451,0.00008518281,0.00008463513,0.0002401872,0.00001240352,0.0001247312,0.0001271229,0.00001844982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005905283,"about_ca_system_score_gemma":0.00005300883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009636913,"about_ca_topic_score_gemma":3.342742e-7,"domain_scores_codex":[0.9986015,0.0001942857,0.0003830083,0.0005120289,0.00007407901,0.0002351144],"domain_scores_gemma":[0.9990898,0.00006564997,0.0001929772,0.0004805436,0.00004886922,0.0001220945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000107412,0.0001785199,0.0007153678,0.00001246918,0.00002740858,1.842215e-7,0.00005228674,0.000004437213,0.9947547,0.0002313714,0.0006874644,0.003228395],"study_design_scores_gemma":[0.0005272211,0.0001468792,0.0001546005,0.00001311366,0.00001570132,0.000002333853,0.00001396946,0.0003599557,0.9937592,0.001290257,0.003514864,0.000201923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9731902,0.0003056475,0.02542118,0.0001955699,0.0001236303,0.0003650378,0.00009867736,0.00004390328,0.0002560768],"genre_scores_gemma":[0.9919252,0.00001978005,0.006097243,0.0002507082,0.00052113,0.00008282714,0.0009110951,0.00002949709,0.000162526],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01932394,"threshold_uncertainty_score":0.693016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01454722767127396,"score_gpt":0.240887174482096,"score_spread":0.226339946810822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}