{"id":"W1996113346","doi":"10.1016/s0960-894x(00)00320-6","title":"6-bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindoles derivatives as novel, potent, and selective 5-HT6 receptor antagonists","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"IDELIX Software (Canada)","funders":"","keywords":"Chemistry; 5-HT6 receptor; Pharmacology; Stereochemistry; Chemical synthesis; Receptor; In vitro; 5-HT receptor; Biochemistry; Serotonin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791263,0.0003423088,0.0004002059,0.0002470154,0.0001455919,0.0001799707,0.000521037,0.0003322237,0.001916236],"category_scores_gemma":[0.0001124875,0.0001720173,0.0001644165,0.0001696322,0.0001575801,0.000197104,0.0001738434,0.0005924081,0.0006957193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002263068,"about_ca_system_score_gemma":0.0002105825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005097626,"about_ca_topic_score_gemma":0.002507127,"domain_scores_codex":[0.9998934,0.00001926904,0.000008180171,0.00001072918,0.00002952422,0.00003882996],"domain_scores_gemma":[0.9999597,0.000005101415,0.00001157985,0.000003425317,0.000005759536,0.00001445527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000957481,0.0001765022,0.0001889029,0.0002869078,0.00002712558,0.0003820461,0.00008480073,0.0007504232,0.9654644,0.001482642,0.001125948,0.02907282],"study_design_scores_gemma":[0.0009094574,0.007696396,0.006729427,0.00004961765,0.0001314563,0.001857437,0.00007797439,0.00341369,0.937062,0.0003312571,0.04167923,0.00006212803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9448581,0.02802912,0.005661165,0.0004984534,0.0002923589,0.0001589126,0.0006080312,0.0003529279,0.01954087],"genre_scores_gemma":[0.9750888,0.01117054,0.004074469,0.0002764001,0.000110337,0.000127119,0.0007035138,0.00002827426,0.008420489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001916236,"threshold_uncertainty_score":0.00641042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01219487046229848,"score_gpt":0.2303156154415231,"score_spread":0.2181207449792247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}