{"id":"W1996141967","doi":"10.1002/1097-0142(20010801)92:3<595::aid-cncr1359>3.0.co;2-d","title":"Phase II study of pemetrexed disodium, a multitargeted antifolate, and cisplatin as first-line therapy in patients with advanced nonsmall cell lung carcinoma","year":2001,"lang":"en","type":"article","venue":"Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Cancer Care Ontario; University of Toronto; Princess Margaret Cancer Centre","funders":"National Cancer Institute; Eli Lilly Canada; Eli Lilly and Company","keywords":"Pemetrexed; Medicine; Antifolate; Performance status; Internal medicine; Phases of clinical research; Gastroenterology; Cisplatin; Neutropenia; Chemotherapy; Surgery; Urology; Oncology; Antimetabolite","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00142957,0.001348084,0.002760933,0.0005606007,0.0005844674,0.0009326601,0.001036845,0.001411509,0.002995104],"category_scores_gemma":[0.001036218,0.0006979459,0.0009067864,0.0004778894,0.001010875,0.0009161521,0.0004875054,0.002852018,0.0008208972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0013165,"about_ca_system_score_gemma":0.002303647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001148972,"about_ca_topic_score_gemma":0.002154102,"domain_scores_codex":[0.9994206,0.0002889666,0.00003808455,0.00009685551,0.00005626133,0.00009923354],"domain_scores_gemma":[0.9989594,0.000147068,0.0001249839,0.00006594322,0.00006017866,0.0006423845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6674027,0.1750422,0.01643064,0.0006833908,0.001010687,0.0007249573,0.0005761977,0.0025438,0.04596236,0.0002404867,0.002517926,0.08686476],"study_design_scores_gemma":[0.387294,0.5923689,0.01209612,0.00002391442,0.0002406032,0.000400354,0.00006920475,0.0009926173,0.003955029,0.0000564775,0.002482438,0.00002037375],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939761,0.001289386,0.0003165477,0.0002909147,0.0001010731,0.00277466,0.0003027245,0.00004010729,0.0009084709],"genre_scores_gemma":[0.9903257,0.001181058,0.001389489,0.0006028375,0.0002239474,0.003238701,0.001239655,0.00001815282,0.001780472],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002995104,"threshold_uncertainty_score":0.0100196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01090290980460885,"score_gpt":0.3144783918800072,"score_spread":0.3035754820753984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}