{"id":"W1996173042","doi":"10.1016/j.jmb.2006.09.058","title":"Crystal Structure of Scytalidoglutamic Peptidase with its First Potent Inhibitor Provides Insights into Substrate Specificity and Catalysis","year":2006,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Substrate specificity; Catalysis; Substrate (aquarium); Chemistry; Crystal structure; Biochemistry; Stereochemistry; Computational biology; Biology; Crystallography; Enzyme; Ecology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009061281,0.0001813426,0.0005311037,0.0003594166,0.00005731909,0.00001594759,0.00007030606,0.0001334105,0.00003741717],"category_scores_gemma":[0.00004415813,0.000118655,0.0001852113,0.0002678437,0.0002154692,0.00007437536,0.00002796744,0.0002285529,9.733425e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005460397,"about_ca_system_score_gemma":0.0001079298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008289001,"about_ca_topic_score_gemma":0.0002464685,"domain_scores_codex":[0.9987858,0.00007531475,0.0005615367,0.0001986883,0.0002182359,0.0001604519],"domain_scores_gemma":[0.9987971,0.00002324843,0.0005109183,0.0001471155,0.0003909757,0.0001306645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002955773,0.0001535898,0.004552045,0.0001005729,0.0002172712,0.0004472439,0.000101093,0.0001461748,0.9936295,0.0001851996,0.00005089015,0.0001208973],"study_design_scores_gemma":[0.002180707,0.001233777,0.01093312,0.0004099419,0.0004047033,0.0009383571,0.0002038883,0.0001316161,0.9823816,0.0007751784,0.0002262861,0.0001807566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996757,0.0009629733,0.001472036,0.0005957638,0.00001705433,0.0001097215,0.00001467605,0.000006619943,0.00006415138],"genre_scores_gemma":[0.998412,0.00004203383,0.001211723,0.00009920869,0.0001483323,7.070945e-7,0.00004568035,0.00001361415,0.0000267212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01124778,"threshold_uncertainty_score":0.4838609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005398207206734547,"score_gpt":0.2276344737455397,"score_spread":0.2222362665388051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}