{"id":"W1996175299","doi":"10.1016/s0304-4165(01)00149-0","title":"Oxazole yellow homodimer YOYO-1-labeled DNA: a fluorescent complex that can be used to assess structural changes in DNA following formation and cellular delivery of cationic lipid DNA complexes","year":2001,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - General Subjects","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research; Medical Research Council Canada","keywords":"DNA; Transfection; Förster resonance energy transfer; Propidium iodide; Biophysics; Biochemistry; Fluorescence; Chemistry; Plasmid; Molecular biology; Cationic polymerization; DNA damage; Biology; Apoptosis; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003713523,0.0004093065,0.0003227856,0.000419809,0.0002725189,0.0003941754,0.000583838,0.0008810917,0.001812275],"category_scores_gemma":[0.0003103693,0.0003942953,0.0001622431,0.0003259851,0.0004558092,0.000418854,0.0003817349,0.0007782506,0.0005292257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007569743,"about_ca_system_score_gemma":0.0003212965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005581763,"about_ca_topic_score_gemma":0.001107074,"domain_scores_codex":[0.9998001,0.00003055103,0.00001135162,0.00005541703,0.0000567528,0.00004580885],"domain_scores_gemma":[0.9997293,0.00005839565,0.00007436877,0.00003471346,0.00002201734,0.00008114582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006195484,0.00001247339,0.0000768392,0.00002289998,0.000002484666,0.00002256231,0.00001200027,0.00002691382,0.999029,0.0001707225,0.00003912854,0.0005229552],"study_design_scores_gemma":[0.00001717973,0.00005255793,0.0009956808,0.000002629977,0.000006309734,0.0001542487,0.000007118527,0.0004393866,0.9973944,0.00003657769,0.0008905626,0.000003437322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9668779,0.001123417,0.02818459,0.0002858092,0.00003739218,0.00007026522,0.0003530181,0.0003999564,0.002667644],"genre_scores_gemma":[0.9738844,0.0006810758,0.01819223,0.0001016713,0.00001500773,0.0001330051,0.0008598068,0.0001161711,0.006016521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001812275,"threshold_uncertainty_score":0.006062686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04580309441650886,"score_gpt":0.2728742519896005,"score_spread":0.2270711575730916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}