{"id":"W1996187280","doi":"10.2741/1369","title":"Eucaryotic replication origin binding proteins","year":2004,"lang":"en","type":"review","venue":"Frontiers in bioscience","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Origin recognition complex; Pre-replication complex; Licensing factor; DNA replication factor CDT1; Control of chromosome duplication; Replication factor C; Eukaryotic DNA replication; Replication (statistics); Origin of replication; DNA replication; Minichromosome maintenance; Cell biology; Biology; Chromatin; Computational biology; Genetics; DNA; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000536663,0.00030779,0.0005408966,0.0002712978,0.00007860483,0.00004530285,0.000842364,0.0003833772,0.000003526559],"category_scores_gemma":[0.0002262142,0.0002783993,0.0001979708,0.0007039524,0.0001568591,0.000007629801,0.0001861255,0.0002050693,0.00002551228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000264408,"about_ca_system_score_gemma":0.0006693499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009758906,"about_ca_topic_score_gemma":0.000002955645,"domain_scores_codex":[0.9977525,0.00009114875,0.0003970421,0.001131209,0.0002279401,0.0004001476],"domain_scores_gemma":[0.9985092,0.000004277419,0.0002582961,0.0011088,0.00002868581,0.0000906884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000007104779,0.0001195112,0.0001262107,0.00508819,0.00004084123,0.00002029766,0.00002978973,0.000007406969,0.006950372,0.0003576652,0.002178211,0.9850744],"study_design_scores_gemma":[0.0001168144,0.0001115208,0.000004473447,0.003303235,0.00004485129,0.00003240035,0.00001333185,0.00001291622,0.003239581,0.0001530031,0.9925562,0.0004116823],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000151598,0.9870219,0.01000241,0.00001450979,0.00128139,0.001169629,0.00002698857,0.00003170225,0.0002999043],"genre_scores_gemma":[0.00006016107,0.9645863,0.03374089,0.00002561885,0.000104376,0.0002255079,0.0001391573,0.00003958324,0.00107847],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.990378,"threshold_uncertainty_score":0.9999668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0280957244890184,"score_gpt":0.3114844892431173,"score_spread":0.2833887647540989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}