{"id":"W1996252269","doi":"10.1021/ol702440f","title":"Total Synthesis of 7-Deoxypancratistatin-1-carboxaldehyde and Carboxylic Acid via Solvent-Free Intramolecular Aziridine Opening:  Phenanthrene to Phenanthridone Cyclization Strategy","year":2007,"lang":"en","type":"article","venue":"Organic Letters","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Brock University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Phenanthrene; Aziridine; Aldehyde; Carboxylic acid; Intramolecular force; Oxidative cleavage; Organic chemistry; Solvent; Cleavage (geology); Catalysis; Ring (chemistry)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002738187,0.0003778475,0.0005362235,0.00008828766,0.0001101292,0.00006779471,0.000426092,0.0001668586,0.0009888436],"category_scores_gemma":[0.0004507961,0.0003602542,0.0001068042,0.0003461644,0.0001686556,0.0001306181,0.000240882,0.0002106762,0.00001482583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001268994,"about_ca_system_score_gemma":0.0000404893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000118774,"about_ca_topic_score_gemma":0.00006053661,"domain_scores_codex":[0.9976847,0.00002744774,0.0006682395,0.0005911787,0.0004289832,0.0005994685],"domain_scores_gemma":[0.9985101,0.0002206887,0.00023887,0.0006642126,0.0000639904,0.0003021643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008268062,0.00009894447,0.0002987386,0.0001271143,0.00009990073,0.0000351127,0.0001932937,0.00001493619,0.9848359,0.00005007503,0.000511073,0.01365218],"study_design_scores_gemma":[0.0006206729,0.00003291291,0.0004463655,0.0001528602,0.0001073098,0.00003305304,0.0001978941,0.0001443166,0.9976969,0.00006915609,0.00006916301,0.0004294396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837914,0.0002460942,0.01328393,0.001795328,0.00007666298,0.0001470429,0.0000433429,0.00008265927,0.0005335608],"genre_scores_gemma":[0.9975655,0.00003753288,0.001624589,0.0003854516,0.0002372568,0.00001243305,0.00002811808,0.00008619765,0.00002293057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01377411,"threshold_uncertainty_score":0.9999244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006047000637751094,"score_gpt":0.2115712114267498,"score_spread":0.2055242107889987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}