{"id":"W1996260537","doi":"10.1073/pnas.1106695108","title":"Human cystic fibrosis airway epithelia have reduced Cl <sup>−</sup> conductance but not increased Na <sup>+</sup> conductance","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Cystic Fibrosis Foundation; Howard Hughes Medical Institute","keywords":"Cystic fibrosis transmembrane conductance regulator; Cystic fibrosis; Amiloride; Transepithelial potential difference; Ion transporter; Apical membrane; Chemistry; Conductance; Respiratory epithelium; Internal medicine; Endocrinology; Biology; Sodium; Lung; Biochemistry; Medicine; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002171242,0.0003190898,0.0004010706,0.000287486,0.0002103463,0.0004935067,0.0001774507,0.0006982906,0.0029504],"category_scores_gemma":[0.0002626772,0.0001470988,0.0003713113,0.000241462,0.0003772563,0.000350343,0.0002125776,0.0004377376,0.000808144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002786429,"about_ca_system_score_gemma":0.0001823868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001931236,"about_ca_topic_score_gemma":0.001370466,"domain_scores_codex":[0.9997618,0.00001924295,0.00002866559,0.00006069495,0.00009564433,0.0000339198],"domain_scores_gemma":[0.9997874,0.0000278718,0.00005227867,0.00003229937,0.00005542943,0.00004473231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004737998,0.000009165087,0.001124342,0.00004713719,0.000006947222,0.000132343,0.00003457552,0.00001517992,0.9968065,0.00007383464,0.000109153,0.001593514],"study_design_scores_gemma":[0.00003006715,0.0007458191,0.1845562,0.00004665492,0.00008317686,0.007944267,0.0004229762,0.0007975203,0.7863877,0.0003983126,0.01854509,0.00004223834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833708,0.007264012,0.003582206,0.0005451452,0.0001075473,0.00005353034,0.001454639,0.0002159722,0.00340617],"genre_scores_gemma":[0.9927502,0.001670394,0.001717345,0.0003239849,0.00001683218,0.00002887745,0.001104349,0.00002533537,0.002362754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0029504,"threshold_uncertainty_score":0.009870052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06686955536441702,"score_gpt":0.3315501372010925,"score_spread":0.2646805818366755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}