{"id":"W1996291781","doi":"10.1111/j.1399-0004.2011.01663.x","title":"Fragile X syndrome therapy: to respond or not to respond may be a matter of methylation","year":2011,"lang":"en","type":"letter","venue":"Clinical Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Methylation; DNA methylation; Fragile X syndrome; Genetics; Medicine; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001139991,0.0003504872,0.0009883031,0.0002111996,0.0009246612,0.0008577082,0.0006262607,0.0111863,0.001993555],"category_scores_gemma":[0.007861205,0.0001744937,0.0005400916,0.0001967112,0.00131157,0.001270326,0.0004047571,0.00953244,0.001275649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001791619,"about_ca_system_score_gemma":0.0005276049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009005474,"about_ca_topic_score_gemma":0.001737323,"domain_scores_codex":[0.9992499,0.0002711721,0.0001158131,0.0001275407,0.0001425415,0.00009305952],"domain_scores_gemma":[0.9978098,0.00153935,0.000155155,0.0000851787,0.0002054435,0.0002051066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001805375,0.0002743719,0.01357423,0.0003812268,0.0001638778,0.07563251,0.0007482003,0.0008271775,0.01125201,0.02129272,0.6772685,0.1967798],"study_design_scores_gemma":[0.001389282,0.001381591,0.02081199,0.0007421179,0.0002893537,0.1423129,0.001312675,0.005208027,0.008595908,0.08406676,0.7335871,0.0003021982],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.00899158,0.004732682,0.0006420243,0.9745713,0.007644451,0.00001881241,0.00007164072,0.00005484175,0.003272763],"genre_scores_gemma":[0.1730358,0.01121112,0.002144003,0.7216108,0.07835448,0.00009662989,0.0001024577,0.00006298949,0.01338169],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.0111863,"threshold_uncertainty_score":0.01299912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0907286160190847,"score_gpt":0.3640855578992097,"score_spread":0.273356941880125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}