{"id":"W1996362582","doi":"10.1021/co200181x","title":"Synthesis of a Unique Isoindoline/Tetrahydroisoquinoline-based Tricyclic Sultam Library Utilizing a Heck-aza-Michael Strategy","year":2012,"lang":"en","type":"article","venue":"ACS Combinatorial Science","topic":"Organic and Inorganic Chemical Reactions","field":"Chemistry","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"National Institute of General Medical Sciences","keywords":"Isoindoline; Chemistry; Tetrahydroisoquinoline; Michael reaction; Intramolecular force; Heck reaction; Tricyclic; Rhodanine; Stereochemistry; Methylenedioxy; Enantioselective synthesis; Combinatorial chemistry; Organic chemistry; Palladium; Catalysis; Alkyl","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001500696,0.0003753878,0.0004767137,0.0004435255,0.0001807869,0.0002965514,0.0004486732,0.0001526837,0.002509967],"category_scores_gemma":[0.0001290531,0.0001450293,0.0002410486,0.000453648,0.0001495258,0.0002166791,0.0003206123,0.00027804,0.001153581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000280937,"about_ca_system_score_gemma":0.0002714728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004362816,"about_ca_topic_score_gemma":0.001237591,"domain_scores_codex":[0.9999056,0.00001216702,0.000008587685,0.00002100482,0.00002833938,0.00002427137],"domain_scores_gemma":[0.9999508,0.00000490123,0.000007091776,0.000007766659,0.00001338152,0.00001621804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001100552,0.00008251495,0.0004309116,0.000214909,0.00003425491,0.0004582274,0.00009705379,0.0007107141,0.9560245,0.0006182144,0.000601253,0.04061733],"study_design_scores_gemma":[0.00005059867,0.0009862442,0.001783652,0.00001715895,0.00008629973,0.001052994,0.00005665361,0.001408759,0.9737202,0.0001402277,0.02067441,0.00002295733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9258048,0.003568407,0.03966939,0.0002216239,0.00007018837,0.0005865249,0.002423405,0.001080416,0.02657525],"genre_scores_gemma":[0.9511634,0.003074901,0.02775034,0.0001473491,0.00001937321,0.000189209,0.002695763,0.00006948089,0.0148901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002509967,"threshold_uncertainty_score":0.008396745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01610409056221697,"score_gpt":0.2514417153926269,"score_spread":0.23533762483041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}