{"id":"W1996412513","doi":"10.1038/sj.bjc.6604377","title":"SPARC promoter hypermethylation in colorectal cancers can be reversed by 5-Aza-2′deoxycytidine to increase SPARC expression and improve therapy response","year":2008,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Bone and Dental Protein Studies","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Canadian Association of Gastroenterology","keywords":"Demethylating agent; DNA methylation; Cancer research; CpG site; Methylation; Colorectal cancer; Deoxycytidine; Cell growth; DNMT1; Cell culture; Biology; Promoter; Apoptosis; Molecular biology; Cancer; Gene expression; DNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000430854,0.0001389429,0.0004149801,0.0001256689,0.0001094041,0.0000199303,0.00005661566,0.00007981751,0.00009508555],"category_scores_gemma":[0.000272586,0.0001324766,0.0000601656,0.0002157184,0.0001077947,0.0001547513,0.00003796474,0.0003017304,6.24024e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003819619,"about_ca_system_score_gemma":0.0004076879,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008056927,"about_ca_topic_score_gemma":0.001501483,"domain_scores_codex":[0.9986621,0.0001283481,0.0003993978,0.0001991263,0.0003812025,0.0002297851],"domain_scores_gemma":[0.999198,0.00006113219,0.0001891103,0.00007385544,0.0002450464,0.0002328159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01588872,0.0001143842,0.02268196,0.00003018699,0.00006555677,0.001971131,0.001063898,0.000007424515,0.9133464,1.483875e-7,0.01563171,0.02919846],"study_design_scores_gemma":[0.01286953,0.002392745,0.505541,0.001712302,0.00005535157,0.005616443,0.0004915908,0.00002364345,0.4586435,0.00002864925,0.01226912,0.0003561657],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985943,0.01121521,0.000007554809,0.001993902,0.0001472052,0.0005257622,0.0000620003,0.000008280892,0.0000970859],"genre_scores_gemma":[0.9907998,0.007167245,0.0004396828,0.0008472507,0.0001981268,0.00004639506,0.000003569667,0.0000228009,0.0004751394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.482859,"threshold_uncertainty_score":0.9985485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01766955580061805,"score_gpt":0.2800406018607796,"score_spread":0.2623710460601615,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}