{"id":"W1996442931","doi":"10.1371/journal.ppat.1000213","title":"Extracellular DNA Chelates Cations and Induces Antibiotic Resistance in Pseudomonas aeruginosa Biofilms","year":2008,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":703,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Biofilm; Pseudomonas aeruginosa; Microbiology; Operon; Extracellular; DNA; Extracellular polymeric substance; Bacterial outer membrane; Biology; Chemistry; Antibiotic resistance; Bacteria; Biochemistry; Antibiotics; Escherichia coli; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009151331,0.0001693001,0.0001735644,0.00006434755,0.0001464265,0.0000208568,0.00008647132,0.0001909075,0.000008611342],"category_scores_gemma":[0.00006860425,0.0001679474,0.00004619002,0.000137533,0.0001436347,0.000007410332,0.00006021469,0.00009746695,0.00001011697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001029807,"about_ca_system_score_gemma":0.00005207324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001899408,"about_ca_topic_score_gemma":0.0001004985,"domain_scores_codex":[0.9989598,0.00005409321,0.0002238443,0.0003922337,0.00008971414,0.0002803535],"domain_scores_gemma":[0.9995102,0.00001370537,0.00007306058,0.0002731111,0.00004601001,0.00008390129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002260978,0.00008087952,0.0111232,0.00001775745,0.00001865805,0.00004444348,0.0001722609,8.013023e-7,0.988215,0.00009787412,0.0000769097,0.0001296516],"study_design_scores_gemma":[0.0003281386,0.00005785496,0.05084631,0.00004258905,0.00001762547,0.0000435469,0.00006802694,0.00000969369,0.9465228,0.00001259588,0.001799042,0.0002517703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952238,0.003767016,0.000004716646,0.0002088533,0.00007950609,0.0001608137,0.00004551766,0.00001705783,0.000492761],"genre_scores_gemma":[0.9959828,0.000938014,0.002253408,0.00005470396,0.0001272358,0.000003703008,0.0001010126,0.00002247264,0.0005167077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04169215,"threshold_uncertainty_score":0.6848698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01710146128585383,"score_gpt":0.215127602045715,"score_spread":0.1980261407598612,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}