{"id":"W1996449038","doi":"10.1371/journal.pone.0122230","title":"Na+/H+ Exchanger Isoform 1 Induced Cardiomyocyte Hypertrophy Involves Activation of p90 Ribosomal S6 Kinase","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Menzies Centre for Australian Studies, King's College London, University of London; Qatar University; Fonds National de la Recherche Luxembourg; Qatar National Research Fund; King's College London; University of Alberta","keywords":"GATA4; Phosphorylation; Muscle hypertrophy; Sodium–hydrogen antiporter; Kinase; Gene isoform; Internal medicine; Cell biology; Protein kinase A; Ribosomal s6 kinase; Endocrinology; Pathogenesis; Biology; Chemistry; Molecular biology; Gene expression; Gene; Medicine; P70-S6 Kinase 1; Biochemistry; Protein kinase B","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135487,0.0003626601,0.0002340332,0.0001438228,0.0001251086,0.0001556592,0.0001085549,0.0001483347,0.00151894],"category_scores_gemma":[0.00006964985,0.00013729,0.0002778137,0.00007946435,0.0001825968,0.0001786589,0.0001896984,0.000445969,0.0003474137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001840304,"about_ca_system_score_gemma":0.0001454076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002429355,"about_ca_topic_score_gemma":0.0003077501,"domain_scores_codex":[0.9998938,0.00001572168,0.000008775585,0.00002723518,0.00002586989,0.00002852369],"domain_scores_gemma":[0.9999601,0.000005312486,0.000013982,0.000004636657,0.00000402789,0.0000120293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001176548,0.00001826381,0.0001848933,0.00003318383,0.000003926208,0.00003724244,0.000006206593,0.00002180693,0.9987442,0.00004840003,0.000021331,0.0007629019],"study_design_scores_gemma":[0.00004173668,0.0005540819,0.02957891,0.000006571855,0.00001888166,0.0004140211,0.00003081726,0.0009084365,0.9664901,0.0001029236,0.001847025,0.000006462691],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917687,0.002785463,0.002984473,0.0001469512,0.00005714594,0.00002766477,0.000274135,0.0001037911,0.001851649],"genre_scores_gemma":[0.9939291,0.001549368,0.002029301,0.00004301647,0.00001919461,0.00003296645,0.0003702616,0.00001494111,0.002011721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00151894,"threshold_uncertainty_score":0.005081356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07549305168839228,"score_gpt":0.2534494469326198,"score_spread":0.1779563952442275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}