{"id":"W1996450064","doi":"10.1038/nmeth.1454","title":"Targeted gene deletions in C. elegans using transposon excision","year":2010,"lang":"en","type":"article","venue":"Nature Methods","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Transposable element; Biology; Caenorhabditis elegans; Genetics; Gene; Insert (composites); Transposase; Genome; DNA; Sleeping Beauty transposon system; Gene knockout; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004345755,0.0001225933,0.0001173789,0.00007854637,0.00003992455,0.00001041463,0.0001322184,0.0005211279,0.00002433025],"category_scores_gemma":[0.0001956489,0.0001195183,0.00007208467,0.0001755615,0.00002197407,0.000002253868,0.00002420525,0.0005643332,8.176938e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007098994,"about_ca_system_score_gemma":0.00003201338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001436801,"about_ca_topic_score_gemma":0.0001004031,"domain_scores_codex":[0.9992399,0.00007697676,0.0001485431,0.0002579783,0.00007608141,0.0002004829],"domain_scores_gemma":[0.9995756,0.00002742595,0.00002199203,0.0002727708,0.00004308164,0.00005909318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001520969,0.00001869552,0.0003881897,0.000005957915,0.000007599035,0.000002402779,0.00003054711,0.001742112,0.9887826,0.00003380378,0.00003284954,0.008940022],"study_design_scores_gemma":[0.000263995,0.00003091291,0.003914832,0.000005274782,0.00001102591,0.00001668876,0.00001051003,0.003691707,0.9645554,0.0000869873,0.02726063,0.0001520233],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5492061,0.001395373,0.4486808,0.00004590609,0.0004567058,0.00007440699,0.000006108547,0.00001013425,0.0001244667],"genre_scores_gemma":[0.5914507,0.00003797768,0.4081641,0.0000644703,0.0001863916,0.000003954527,0.00003087213,0.00001561937,0.00004588673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04224458,"threshold_uncertainty_score":0.4873815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008930957968437984,"score_gpt":0.4123721986019953,"score_spread":0.4034412406335573,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}