{"id":"W1996482349","doi":"10.1158/1538-7445.am10-5349","title":"Abstract 5349: Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type-I IFN production","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University","funders":"","keywords":"Vesicular stomatitis virus; Oncolytic virus; P70-S6 Kinase 1; PI3K/AKT/mTOR pathway; Interferon; Cancer research; Cancer; mTORC1; Virology; Lactobacillus rhamnosus; Biology; Virus; Medicine; Cell biology; Signal transduction; Lactobacillus; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008410705,0.0004594049,0.0003708466,0.000315841,0.0001559064,0.0002990028,0.0002278149,0.0003184917,0.008609229],"category_scores_gemma":[0.00007626921,0.0001296533,0.0002651145,0.0001596465,0.0001698104,0.0001673595,0.0001333805,0.0007296699,0.001881028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003421072,"about_ca_system_score_gemma":0.0002029614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005704443,"about_ca_topic_score_gemma":0.0007806709,"domain_scores_codex":[0.9999106,0.00001414765,0.00001036069,0.00001341666,0.00002549841,0.00002593166],"domain_scores_gemma":[0.9999599,0.000008729806,0.00001072996,0.000005115744,0.000004876559,0.00001057994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008971521,0.0001848386,0.0001414848,0.0000612707,0.00001252426,0.00009552744,0.000006362744,0.0001048723,0.9918082,0.000227188,0.001745079,0.004715479],"study_design_scores_gemma":[0.0001202491,0.001383733,0.004809274,0.00001813858,0.00003580021,0.0003338616,0.00001172448,0.00093327,0.9842408,0.0001033099,0.008004309,0.000005521787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9552019,0.006359215,0.002362836,0.001347514,0.0009219634,0.0001552014,0.004385311,0.0005778098,0.02868829],"genre_scores_gemma":[0.9698286,0.002959397,0.002541949,0.0003406277,0.0001421193,0.0001044199,0.003277041,0.0001002029,0.0207056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008609229,"threshold_uncertainty_score":0.02880079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02940145957915326,"score_gpt":0.3774638763532975,"score_spread":0.3480624167741442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}