{"id":"W1996486782","doi":"10.3390/pathogens2010033","title":"Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance","year":2013,"lang":"en","type":"review","venue":"Pathogens","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Toronto","funders":"Calgary Laboratory Services","keywords":"Plasmodium falciparum; Malaria; Chloroquine; Hsp90; Artesunate; Drug resistance; Reversing; Antimalarial Agent; Biology; Artemisinin; Virology; First line; Heat shock protein; Immunology; Pharmacology; Medicine; Microbiology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000772961,0.0006049941,0.001177589,0.0001609122,0.000310545,0.0001166576,0.0007524974,0.0009454816,0.0001445244],"category_scores_gemma":[0.0007644432,0.0005504934,0.0005959991,0.0002911172,0.0001241031,0.000007111358,0.0006347914,0.0006031848,0.0003198099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001245152,"about_ca_system_score_gemma":0.0007429885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002203965,"about_ca_topic_score_gemma":0.0000145427,"domain_scores_codex":[0.9962136,0.0005448846,0.0007146669,0.001085787,0.0004679862,0.0009731004],"domain_scores_gemma":[0.9982826,0.00003655327,0.0002592825,0.0009486373,0.0002037704,0.000269224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007745763,0.0001341558,0.00001028785,0.01826626,0.000549546,0.0001851496,0.00004825848,0.000006674725,0.04995853,0.00007910482,0.04062007,0.8900645],"study_design_scores_gemma":[0.0001813228,0.00007197804,0.000001160495,0.001702463,0.0001353293,0.00002554208,0.00001009968,0.000007268316,0.001907654,0.000005240925,0.9953696,0.0005823886],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008373649,0.9920709,0.0007471711,0.00005030213,0.0004427885,0.001528651,0.0004143866,0.00003791441,0.004624201],"genre_scores_gemma":[0.00007192836,0.9868275,0.005848079,0.00002769272,0.00136535,0.0002961276,0.001144344,0.0001604403,0.004258529],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9547495,"threshold_uncertainty_score":0.9996946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04608940587345472,"score_gpt":0.3357684016688173,"score_spread":0.2896789957953625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}