{"id":"W1996509853","doi":"10.1007/s11357-015-9788-7","title":"PMT1 deficiency enhances basal UPR activity and extends replicative lifespan of Saccharomyces cerevisiae","year":2015,"lang":"en","type":"article","venue":"AGE","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Aging","funders":"National Institute of Environmental Health Sciences; Natural Science Foundation of Guangdong Province; Guangdong Medical College; National Institute on Aging; National Cancer Institute; National Institutes of Health; National Natural Science Foundation of China","keywords":"Unfolded protein response; Endoplasmic reticulum; Saccharomyces cerevisiae; Cell biology; Biology; Chemistry; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001260606,0.0005595055,0.0003690833,0.0003032236,0.0001619737,0.0005461976,0.0003739778,0.0003438786,0.001860763],"category_scores_gemma":[0.0001458672,0.0002294557,0.000294721,0.0002946041,0.0002096861,0.0003171116,0.0003788955,0.0006876896,0.0006066958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003925285,"about_ca_system_score_gemma":0.0002090614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000866622,"about_ca_topic_score_gemma":0.0007757273,"domain_scores_codex":[0.9998784,0.00001495302,0.00002663753,0.00003160294,0.00002321081,0.00002515347],"domain_scores_gemma":[0.9997877,0.00003883741,0.00005372376,0.00003524799,0.00001772668,0.00006672965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002596118,0.00003468903,0.0001665653,0.0000341203,0.00000517896,0.00007244405,0.00001226646,0.0000857256,0.9982238,0.00007357422,0.00005005673,0.0009818468],"study_design_scores_gemma":[0.00001691209,0.0001422779,0.003491729,0.000006779507,0.00001801774,0.0001534017,0.00003175417,0.0008392978,0.9939098,0.00004551253,0.001337737,0.000006654716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958741,0.001096181,0.00108369,0.0001032977,0.00003900996,0.00001044234,0.0009614586,0.0001492541,0.0006824629],"genre_scores_gemma":[0.9947401,0.0006275269,0.0008764821,0.00004367326,0.00001355479,0.00001542447,0.001061503,0.0000594882,0.002562306],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001860763,"threshold_uncertainty_score":0.006224871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01696538908347067,"score_gpt":0.279697402759934,"score_spread":0.2627320136764633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}