{"id":"W1996518469","doi":"10.1016/j.cjca.2014.07.237","title":"TERT-BUTYLHYDROQUINONE RESCUES CYCLOSPORINE-A MEDIATED IMPAIRMENT IN VASCULAR FUNCTION VIA AUGMENTING PHOSPHORYLATION OF THE TRANSCRIPTION FACTOR NRF2","year":2014,"lang":"en","type":"article","venue":"Canadian Journal of Cardiology","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Public Health","funders":"","keywords":"Medicine; Superoxide dismutase; Oxidative stress; Phosphorylation; Pharmacology; ED50; Acetylcholine; Antioxidant; Endothelial dysfunction; Transplantation; Internal medicine; Endocrinology; Biochemistry; Chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001717644,0.0003782845,0.0005293826,0.0002577043,0.0002672626,0.0002632132,0.000338297,0.0004261715,0.002739828],"category_scores_gemma":[0.0001648633,0.0002140471,0.0002922821,0.0001450804,0.0003946657,0.0003398076,0.0001851007,0.001286835,0.0004118911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001948319,"about_ca_system_score_gemma":0.0004748144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001133709,"about_ca_topic_score_gemma":0.00178666,"domain_scores_codex":[0.9998902,0.00001614847,0.00001063027,0.00002042897,0.00002371269,0.00003883424],"domain_scores_gemma":[0.9997709,0.00002594988,0.00005365931,0.0000342462,0.00002359953,0.00009166707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000865359,0.0001590451,0.00005540941,0.00005195566,0.00001377873,0.00006180664,0.00001897995,0.00007029178,0.9970291,0.00009658183,0.0001657931,0.001411856],"study_design_scores_gemma":[0.0002717673,0.002066494,0.004156217,0.0000111874,0.00004796067,0.0002336268,0.00007127321,0.0008358306,0.9893571,0.0002096295,0.002723756,0.00001517028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941173,0.001336453,0.002006497,0.0004721335,0.0001614361,0.00004635855,0.0003524915,0.0003384018,0.001168954],"genre_scores_gemma":[0.9961493,0.000686019,0.0007390055,0.00006340876,0.00002762357,0.00002283746,0.0002564949,0.00003164051,0.0020236],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002739828,"threshold_uncertainty_score":0.009165585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006089150186754869,"score_gpt":0.1908708658472184,"score_spread":0.1847817156604636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}