{"id":"W1996531785","doi":"10.2217/fon.09.26","title":"Role of The<i>MTHFR</i>Polymorphisms in Cancer Risk Modification and Treatment","year":2009,"lang":"en","type":"review","venue":"Future Oncology","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Methylenetetrahydrofolate reductase; Single-nucleotide polymorphism; Medicine; Pharmacogenetics; Pharmacology; Antimetabolite; Cancer; Methotrexate; Bioinformatics; Cancer research; Allele; Internal medicine; Genetics; Biology; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001781799,0.000245318,0.0008463153,0.0005614488,0.000248629,0.0008559655,0.0005193471,0.001194219,0.001988905],"category_scores_gemma":[0.007093634,0.0001313974,0.001055268,0.001097791,0.000373127,0.0002958161,0.000310287,0.001070036,0.0003521746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008721004,"about_ca_system_score_gemma":0.0009143901,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004452812,"about_ca_topic_score_gemma":0.002646961,"domain_scores_codex":[0.998363,0.000851777,0.0001264979,0.0002321878,0.0003095148,0.000117031],"domain_scores_gemma":[0.9975562,0.0009619875,0.000824136,0.0001434627,0.0002861383,0.00022815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002392734,0.0007300379,0.3132302,0.001998309,0.003796299,0.0005843462,0.0001900957,0.00199651,0.003309511,0.005479427,0.01551378,0.6507788],"study_design_scores_gemma":[0.0007629595,0.002208773,0.8326066,0.002977795,0.005964813,0.001732185,0.0002415521,0.004893309,0.002985137,0.01181101,0.1336861,0.0001298495],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1836396,0.7343199,0.005579494,0.0508243,0.001506624,0.0001356745,0.002039582,0.0001706643,0.02178423],"genre_scores_gemma":[0.7676429,0.2127082,0.004352089,0.007087023,0.002940287,0.0001634177,0.001422831,0.00004115955,0.003642106],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004452812,"threshold_uncertainty_score":0.009423196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05384394065183835,"score_gpt":0.4075805005562327,"score_spread":0.3537365599043944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}