{"id":"W1996548885","doi":"10.1016/j.bmcl.2014.09.014","title":"5-(4-((4-[18F]fluorobenzyl)oxy)-3-methoxybenzyl)pyrimidine-2,4-diamine: A selective dual inhibitor for potential PET imaging of Trk/CSF-1R","year":2014,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Neurological Institute and Hospital; University of Alberta; McGill University","funders":"","keywords":"Chemistry; Pyrimidine; Diamine; Trk receptor; Dual (grammatical number); Stereochemistry; Combinatorial chemistry; Biochemistry; Organic chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005758806,0.0004956198,0.0007912423,0.0000730803,0.0001837693,0.00002652883,0.0002928079,0.0001421423,0.0003596224],"category_scores_gemma":[0.000679451,0.0004711164,0.0003421829,0.000457825,0.0004762857,0.0001028969,0.00008069919,0.0006208497,0.00001292854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002236835,"about_ca_system_score_gemma":0.000205725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001503711,"about_ca_topic_score_gemma":2.152352e-7,"domain_scores_codex":[0.9969441,0.00004898942,0.0008280734,0.0008156905,0.0006497598,0.0007133613],"domain_scores_gemma":[0.997858,0.0003233149,0.0003439511,0.0005989822,0.000315545,0.0005602269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004075867,0.0002480922,0.0003623501,0.0009513891,0.0001543344,0.00006042354,0.000090067,0.000004845478,0.9815539,0.00002157656,0.01525679,0.0008886536],"study_design_scores_gemma":[0.004248324,0.00009873891,0.0006476486,0.0002258657,0.0007096607,0.001202047,0.0002233733,0.001473345,0.9840044,0.00005621921,0.006682135,0.0004282564],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.968672,0.0004680162,0.009182234,0.01902433,0.0002455887,0.0007669269,0.0001082313,0.0002045637,0.001328078],"genre_scores_gemma":[0.9907576,0.00002967809,0.003197777,0.002353548,0.002925247,0.0001173994,0.0002578484,0.00008825721,0.0002726808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02208554,"threshold_uncertainty_score":0.999774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01027282847372922,"score_gpt":0.2735534998517373,"score_spread":0.263280671378008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}