{"id":"W1996553163","doi":"10.1021/bi060268o","title":"Characterization of the Hydrodynamic Properties of the Folding Transition State of an SH3 Domain by Magnetization Transfer NMR Spectroscopy","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"SH3 domain; Chemistry; Protein folding; Nuclear magnetic resonance spectroscopy; Folding (DSP implementation); Magnetization; Chemical physics; Phi value analysis; Crystallography; Downhill folding; Stereochemistry; Physics; Proto-oncogene tyrosine-protein kinase Src; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791868,0.0001746101,0.000117305,0.0001466191,0.0001390688,0.0001618437,0.0001291335,0.0001511951,0.0004609852],"category_scores_gemma":[0.0004243829,0.00005681974,0.00009707152,0.0001337535,0.000250451,0.0001736883,0.0001028773,0.0003163036,0.0001530426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002464715,"about_ca_system_score_gemma":0.0001253523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009055858,"about_ca_topic_score_gemma":0.0005563601,"domain_scores_codex":[0.9999431,0.00001075285,0.000002745115,0.00001204531,0.00002176469,0.000009489103],"domain_scores_gemma":[0.999864,0.00004341254,0.00003097185,0.000009378829,0.00002785791,0.00002429627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003995137,0.000008178838,0.0006798512,0.00001135626,0.000002095713,0.00001606763,0.00001773985,0.0001835842,0.9979824,0.00007844174,0.00001692508,0.0009633498],"study_design_scores_gemma":[0.000008382453,0.0000723415,0.0148479,0.000003188589,0.000004962722,0.0001480383,0.00002478861,0.007347514,0.9766929,0.0001619694,0.0006803241,0.000007624702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898778,0.0002831076,0.009052132,0.0000279583,0.000002923098,0.000009785602,0.0001835776,0.00005570786,0.0005070869],"genre_scores_gemma":[0.9959496,0.0001650693,0.003243209,0.00001335007,0.00000242531,0.00001081575,0.0003067488,0.00001191838,0.0002969884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009055858,"threshold_uncertainty_score":0.001800597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.001811379388664548,"score_gpt":0.1668203314403982,"score_spread":0.1650089520517336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}