{"id":"W1996566461","doi":"10.1021/jp407536p","title":"Conformational Biases of Linear Motifs","year":2013,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Waterloo","funders":"Canadian Institutes of Health Research","keywords":"Affinities; Molecular dynamics; Function (biology); Amino acid; Amino acid residue; Binding affinities; Protein structure; Biophysics; Computational biology; Chemistry; Peptide sequence; Biology; Biochemistry; Genetics; Computational chemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007415879,0.00006695418,0.0001078523,0.000005230982,0.00002514764,0.000004781537,0.0002032891,0.00004180372,0.0000388612],"category_scores_gemma":[0.0001010713,0.0000403193,0.00009591316,0.00003205387,0.00009255709,0.000005922787,0.00004437587,0.0001009798,0.000003323906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004091793,"about_ca_system_score_gemma":0.00004761034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003937346,"about_ca_topic_score_gemma":9.858468e-8,"domain_scores_codex":[0.999553,0.00001399489,0.0001830388,0.00003626808,0.0001379756,0.00007571936],"domain_scores_gemma":[0.9993851,0.00003246076,0.0002128426,0.0001318144,0.0001955316,0.00004224697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003086553,0.00003102061,0.00003326525,0.00001760981,0.00003598457,2.142272e-7,0.00004436112,0.0009311595,0.9977366,0.00001987613,0.0006783206,0.0004407527],"study_design_scores_gemma":[0.0002140409,0.00009872121,0.0002931143,0.00001481392,0.0000205618,0.0000438511,0.00006076079,0.001740209,0.9961508,0.0006335991,0.0006781438,0.00005137091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981527,0.00009580144,0.0007523273,0.0001018774,0.00001576518,0.00003649821,0.00001095144,0.00000117366,0.0008329101],"genre_scores_gemma":[0.9991207,0.00001548096,0.0001910912,0.00005277548,0.0004731767,7.76802e-7,0.00001458438,0.000004720959,0.0001267319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001585757,"threshold_uncertainty_score":0.1644173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007025385770581092,"score_gpt":0.2387604257125094,"score_spread":0.2317350399419283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}