{"id":"W1996566461","doi":"10.1021/jp407536p","title":"Conformational Biases of Linear Motifs","year":2013,"lang":"en","type":"article","venue":"The Journal of Physical Chemistry B","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Waterloo","funders":"Canadian Institutes of Health Research","keywords":"Affinities; Molecular dynamics; Function (biology); Amino acid; Amino acid residue; Binding affinities; Protein structure; Biophysics; Computational biology; Chemistry; Peptide sequence; Biology; Biochemistry; Genetics; Computational chemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001981989,0.0002189722,0.000234621,0.0002958871,0.0005069748,0.000624862,0.0004254074,0.0003063508,0.006724155],"category_scores_gemma":[0.0008724873,0.0002630637,0.0002820825,0.000199704,0.0004569242,0.0008189603,0.0004423378,0.0005694423,0.0006363097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004468124,"about_ca_system_score_gemma":0.0003755093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001272808,"about_ca_topic_score_gemma":0.001656382,"domain_scores_codex":[0.9998649,0.00001652612,0.000006957567,0.0000418478,0.00002478079,0.00004493606],"domain_scores_gemma":[0.9997039,0.00008552885,0.00004609357,0.0000425271,0.00004804414,0.00007382349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002087811,0.0004564765,0.02421553,0.0006386146,0.0003093752,0.001626647,0.0007884484,0.1689378,0.6776395,0.06623852,0.005430823,0.05163043],"study_design_scores_gemma":[0.000285033,0.001321861,0.02714765,0.0001071277,0.0002127648,0.001148653,0.0007972897,0.6966163,0.2107032,0.04253587,0.01886626,0.0002579996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862626,0.0003289573,0.007599744,0.0001027859,0.0000376275,0.00002496591,0.0001719437,0.0001380631,0.005333304],"genre_scores_gemma":[0.9964147,0.0001256979,0.002136766,0.00006832899,0.000004338728,0.00002363539,0.0002188501,0.00004581424,0.0009619209],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006724155,"threshold_uncertainty_score":0.02249449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007025385770581092,"score_gpt":0.2387604257125094,"score_spread":0.2317350399419283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}