{"id":"W1996592124","doi":"10.1016/s0896-6273(02)00615-3","title":"Increased Sensitivity to N-Methyl-D-Aspartate Receptor-Mediated Excitotoxicity in a Mouse Model of Huntington's Disease","year":2002,"lang":"en","type":"article","venue":"Neuron","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":594,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Pacific Centre for Reproductive Medicine","funders":"","keywords":"Excitotoxicity; NMDA receptor; Huntington's disease; Huntingtin; Glutamate receptor; AMPA receptor; Neuroscience; Programmed cell death; Biology; Quinolinate; Genetically modified mouse; Neurodegeneration; Medium spiny neuron; Quinolinic acid; Neuron; Receptor; Transgene; Cell biology; Internal medicine; Central nervous system; Basal ganglia; Apoptosis; Biochemistry; Medicine; Disease; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001840086,0.0003025072,0.0003400175,0.0002675781,0.00008281498,0.00003522205,0.0002557734,0.00005183707,0.00008060045],"category_scores_gemma":[0.004574401,0.000323689,0.0001073293,0.0006131039,0.0001325965,0.0001633535,0.0001666666,0.0002190639,0.0001668889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004059521,"about_ca_system_score_gemma":0.00005144559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007878988,"about_ca_topic_score_gemma":0.00004874005,"domain_scores_codex":[0.996805,0.0008548354,0.0004082482,0.0008850095,0.0005387351,0.0005081946],"domain_scores_gemma":[0.9981548,0.0005123174,0.0001509441,0.0005947503,0.00007544777,0.0005116949],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001522565,0.0005327764,0.004179507,0.00002869781,0.000001222395,0.00001584231,0.0001591794,0.02046661,0.9738952,0.00003086976,0.0003127501,0.0002250852],"study_design_scores_gemma":[0.0005573086,0.00009208213,0.01160942,0.00001623924,0.000004990251,2.906167e-7,0.000006416755,0.09054378,0.8968498,0.00002592249,0.00004734553,0.0002464186],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979692,0.000005933088,0.0001424301,0.0003248572,0.0001110082,0.0006422296,0.0004627054,0.0001146459,0.0002270173],"genre_scores_gemma":[0.9970713,0.00003356092,0.0002298016,0.002163625,0.00003493538,0.00005768569,0.000006487905,0.00005345807,0.0003491093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07704541,"threshold_uncertainty_score":0.9999215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03779730953330144,"score_gpt":0.2517387210980842,"score_spread":0.2139414115647828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}