{"id":"W1996592124","doi":"10.1016/s0896-6273(02)00615-3","title":"Increased Sensitivity to N-Methyl-D-Aspartate Receptor-Mediated Excitotoxicity in a Mouse Model of Huntington's Disease","year":2002,"lang":"en","type":"article","venue":"Neuron","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":594,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Pacific Centre for Reproductive Medicine","funders":"","keywords":"Excitotoxicity; NMDA receptor; Huntington's disease; Huntingtin; Glutamate receptor; AMPA receptor; Neuroscience; Programmed cell death; Biology; Quinolinate; Genetically modified mouse; Neurodegeneration; Medium spiny neuron; Quinolinic acid; Neuron; Receptor; Transgene; Cell biology; Internal medicine; Central nervous system; Basal ganglia; Apoptosis; Biochemistry; Medicine; Disease; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002995278,0.0008390784,0.0006049042,0.001501577,0.0002760189,0.0004971258,0.0004169348,0.001159968,0.002156692],"category_scores_gemma":[0.0002551246,0.0004632425,0.0004536028,0.0003355188,0.0005755232,0.0005525869,0.0003540264,0.001396661,0.0003379258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005622762,"about_ca_system_score_gemma":0.0002165845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001110764,"about_ca_topic_score_gemma":0.00173113,"domain_scores_codex":[0.9996567,0.00005998966,0.00004899539,0.00008239026,0.00008602616,0.00006589285],"domain_scores_gemma":[0.999622,0.00006158949,0.0001048244,0.00004404206,0.00003517939,0.0001323243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000226247,0.00004780994,0.0001735883,0.00002842872,0.00001691714,0.0001568066,0.00002298501,0.0000597687,0.9987378,0.0001248366,0.00004134434,0.0003636153],"study_design_scores_gemma":[0.0001100313,0.001002721,0.01161504,0.00003215267,0.0001494137,0.001578498,0.00009033484,0.001540479,0.9819709,0.0003565586,0.001529649,0.00002425334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956226,0.001145328,0.001439738,0.0001580879,0.00004608347,0.00002689082,0.0004951548,0.0001445511,0.0009217675],"genre_scores_gemma":[0.9935647,0.0008806747,0.001336813,0.00008743843,0.00001320375,0.00004949038,0.0004503156,0.00005150918,0.003565967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002156692,"threshold_uncertainty_score":0.007214904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03779730953330144,"score_gpt":0.2517387210980842,"score_spread":0.2139414115647828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}